I invented the dosing regimens for autoimmunity and I am pretty sure dosage doesn't matter very much at all. We probably give twice as much as necessary. There are all sorts of variations on the way the dosing is described but we have no real evidence it matters. If B cells are depleted, which they are with all these variations, then the objective has been achieved. I spent some time trying to work out if different doses were important in RA but concluded that unless you go very much lower the results are similar.