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Rituximab and placebo response

Discussion in 'Drug and supplement treatments' started by Jonathan Edwards, May 27, 2019.

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  1. Ravn

    Ravn Senior Member (Voting Rights)

    Messages:
    2,306
    Location:
    Aotearoa New Zealand
    Ah now @Marky. That would be the nocebo* effect. Deep, deep down in your heart you were worried Ritux wasn't going to work - so of course it didn't.

    *Nocebo: defined as punishment for cynical souls who refuse to believe in magic, consciously or subconsciously. Expect a publication in a prestigious journal anytime soon.**

    ** There probably already is but I haven't the stomach to look.
     
    Ravn, Dec 1, 2020
    #161
    DigitalDrifter, MEMarge, lycaena and 5 others like this.
  2. leokitten

    leokitten Senior Member (Voting Rights)

    Messages:
    922
    Location:
    U.S.
    Yes exactly, I always wondered why they didn’t use some type of more quantitative physical exertion test for the primary endpoint. Ampligen did for their trial, though not sure if there were criticisms of their specific choice of test.
     
    Last edited: Dec 2, 2020
    leokitten, Dec 2, 2020
    #162
    Marky likes this.
  3. Midnattsol

    Midnattsol Moderator Staff Member

    Messages:
    4,027
    That's your cynical soul right there :whistle:

    How much do we have to exert ourselves to say something is not working good enough (if it is working at all)? I miss doing heavy workouts and hiking tall mountains, but I would still be interested in something that allows the "exertion" of daily living to not be a problem on bad days even if I can't do the more strenuous things.
     
    Midnattsol, Dec 2, 2020
    #163
    ahimsa, Ravn, Sean and 1 other person like this.
  4. Marky

    Marky Senior Member (Voting Rights)

    Messages:
    591
    Location:
    Norway
    It varies greatly between ME-patients.. In my first year i would get bad PEM from running, or lifting weights for 30 mins. Last year I got bad PEM from trying to make dinner.
     
    Marky, Dec 2, 2020
    #164
    leokitten, MEMarge, ahimsa and 1 other person like this.
  5. mango

    mango Senior Member (Voting Rights)

    Messages:
    3,046
    mango, Dec 13, 2020
    #165
    Snow Leopard, Legend, andypants and 1 other person like this.
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