Ron Davis Q and A -Massachusetts- March 2018

Thanks @Daisymay. I'm not sure he answered that question specifically. The family study that he spoke of may throw some light on that.

Not sure how anyone else views it, but I thought this presentation had a crisper more focussed note. It was interesting that he wasn't trying to group patients into subcategories. Each patient may have a different collection of metabolites which would presumably present with different symptoms. Please jump in scientists- I am not one of you.

I wonder what the other three possible biomarkers are, those where they do not yet have sufficient data. I think I remember that the numbers whose blood has been tested with the nano needle are very small.
 
No information given but they hoped to have an answer about one thread by the end of the summer. Towards the end of the clip if you want to check it.

'There may be ways to manipulate people out of the circuit: they are looking at one primary circuit which they hope to have an answer to by the end of the summer.'
 
If I understood this right, he thinks there is a single underlying mechanism that is capable of producing different symptoms in different patients. He also mentioned seeing different (genetic) mutations in different patients.

I may be wrong, but it sounds kind of like the underlying mechanism may be exposing different underlying genetic weaknesses which would otherwise not be apparent in a healthy person.

Perhaps like giving a garden less water, the weakest plants will be affected first, but the weakest plants are different in every garden.
 
He has only done the nanoneedle test on 10 patients (?) I wonder if he might consider trying it out on a couple of Nancy Klimas GWI patients. If it proved negative then that would go towards showing it is a good test for ME, and if positive then maybe some of the GWI funding might help to develop it further.
 
My only (very basic) grasp of science has been entirely created by the fact that I became ill with ME, so take this with a pinch of salt...

The only thing I don't understand about this is...presumably we got ill many different ways. And even tho we ended up in the same, or similar state, surely there could be various different reasons why we continue to be there, and therefore there can't be a one size-fits-all solution for us? As I said though, I have no real idea about this sort of stuff and happy to defer to those more in the know.
 
Sly Saint said:
He has only done the nanoneedle test on 10 patients (?) I wonder if he might consider trying it out on a couple of Nancy Klimas GWI patients. If it proved negative then that would go towards showing it is a good test for ME, and if positive then maybe some of the GWI funding might help to develop it further.
Click to expand...

There's a thread somewhere that discusses the deformability of red blood cells and GWI.(posted below)
If I have this right, Ron Davis' (with San Jose Univ) research shows the red blood cells do not deform as necessary to fit along narrow capillaries so that full oxygen is not being picked up. Blood is purplish and viscous.

The research on GW patients shows the opposite.
https://www.s4me.info/threads/abnor...s-a-preliminary-study-2018-condon-et-al.3707/

https://www.omf.ngo/2018/03/21/omf-funded-research-red-blood-cell-deformability-in-me-cfs/
 
Binkie4 said:
There's a thread somewhere that discusses the deformability of red blood cells and GWI.(posted below)
If I have this right, Ron Davis' (with San Jose Univ) research shows the red blood cells do not deform as necessary to fit along narrow capillaries so that full oxygen is not being picked up. Blood is purplish and viscous.

The research on GW patients shows the opposite.
https://www.s4me.info/threads/abnor...s-a-preliminary-study-2018-condon-et-al.3707/

https://www.omf.ngo/2018/03/21/omf-funded-research-red-blood-cell-deformability-in-me-cfs/
Click to expand...
but I don't think that is what the nanoneedle test is testing (as far as I remember even Prof Davis doesn't know why the test works; something to do with impedance).

eta: this is the test he does by stressing the cells out with salt(?)
 
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Sly Saint said:
but I don't think that is what the nanoneedle test is testing (as far as I remember even Prof Davis doesn't know why the test works; something to do with impedence).

eta: this is the test he does by stressing the cells out with salt(?)
Click to expand...

As far as I understand I think Prof Davis is looking for a biomarker for ME/ cfs. The closest he has got is by examining pwme red blood cells which do not deform in the same way as non patients. All the cases he has tested ( not very many, both patients and non patients) show this consistent pattern.

I do vaguely remember something about impedance in an earlier video clip but have no recollection of where it fits into this biomarker work.
 
The following is just a small excerpt from the full transcript, which is worth reading (of course). Not sure if we have a thread for this or not.
Dr. Ron Davis said:
So, if we put healthy cells and their serum into the device, it is pretty stable and does not change. If we put in ME/CFS cells and their serum, it doesn’t change. However, if we put a demand on the cells, we require them to consume energy, and that demand is seen in this graph where there is a slight dip in the healthy controls – but they handle that demand quite well and don’t change after that – however the cells from the ME/CFS patient, show a rapid increase in impedance. And that has been shown for every patient we have looked at, and also every healthy control is the same.
Click to expand...
http://www.meaction.net/wp-content/uploads/2015/05/Ron-Davis-Transcript.pdf
 
The one at the beginning of this thread is from March this year, to accompany a viewing of ' unrest'.

The information in the other one seems to be, as @Barry says, from 2015.
 
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