Scientists discover a major brain shift between ages 50 and 75

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Amw66

Senior Member (Voting Rights)
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Scientists have uncovered sweeping changes in how the human brain controls and organizes its genome beginning in midlife, offering new clues to why aging sharply increases the risk of Alzheimer’s and other neurodegenerative diseases. One of the biggest shifts occurred between about ages 50 and 75, when many of the brain’s original immune cells declined and were replaced by cells with more inflammatory characteristics. Researchers also found weakening of cells that help maintain the blood-brain barrier, along with widespread deterioration in the genome’s three-dimensional organization.

Scientists discover a major brain shift between ages 50 and 75 | ScienceDaily https://share.google/HntBLtc0tkjYGRYnL

Link to paper

  1. Nathan R. Zemke, Seoyeon Lee, Sainath Mamde, Bing Yang, Nicole Berchtold, B. Maximiliano Garduño, Hannah S. Indralingam, Weronika M. Bartosik, Pik Ki Lau, Keyi Dong, Emily Hsu, Amanda Yang, Yasmine Tani, Chumo Chen, Qiurui Zeng, Varun Ajith, Liqi Tong, Chanrung Seng, Daofeng Li, Ting Wang, Jingtian Zhou, Joseph R. Ecker, Christopher K. Glass, Carl W. Cotman, Xiangmin Xu, Bing Ren. Epigenetic and 3D genome reprogramming during the aging of the human hippocampus. Science, 2026; 393 (6809) DOI: 10.1126/science.adt8307
 
It was here

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Thread 'Why our memory slips after age 50'

erictopol.substack.com

Why Our Memory Slips After Age 50

Landmark independent studies challenge longstanding dogma for brain aging
erictopol.substack.com erictopol.substack.com

There has been a big shake-up in the understanding for how our brain ages. Until now, the prevailing belief was that our brain tissue shrinks with age, exemplified by the hippocampus, the region tied to memory and learning, as seen via MRI and other imaging modalities. That the microglia immune cells we were born with (embryonic) were the only types to be found in our brain. And the brain aging process was accepted to be a linear, steady deterioration. It turns out all of that was wrong!
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Did anything ever come of the concept of ‘terminal dip’ in memory (if I have remembered the term correctly, or was it ‘terminal drop’)? I am over forty years out of date on memory studies, but when I was an undergraduate one of my tutors, Prof Pat Rabbitt, was working on the idea that findings indicating memory gradually declined with age were an artefact of group studies using average scores. He argued that instead of measuring group effects on the basis of chronological age, you should look at individual changes over time measured backwards from death. When doing this the appearant steady decline was rather replaced with a rapid dip over the last six months of life, regardless of the cause of death.
 
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