"Scientists hail autoimmune breakthrough" - the Guardian

Having waded through the whole paper now, I don’t see any wrong ideas in it such as T cell driven autoimmunity. Regarding citations or lack thereof, that’s always driven by politics.

 

No, I agree. It is just that 95% of people in the field still seem to have a belief in mysterious auto reactive T cells driving the autoantibodies and that is what you are likely to find in their relevant references apart from ours of course. And talking of a 'more widespread correction of autoimmunity' in mysterious terms seems a bit coy when they could refer to our Nature Reviews Immunology article which spells out exactly how that ought to work - but in the sense that there is nothing more to be done!

 

Be good for someone to highlight any BPS nonsense for lupus

 

Have you had a chance to check out Fig 3? The patient with elevated anti-Ro antibody, it barely declined with treatment, and they still had quite elevated levels of fatigue after 3 months. Bad news for Sjogren’s?

 

It is as we found it - slow to fall if at all, although those with lower levels did get a drop.
I am not sure this is interpretable at 3 months though. If pathogenic clones of B cells are destroyed there may be no long term replenishment of anti-Ro from cycling new B cell clones. The crucial thing is what happens from a year onwards, when any re-engagement of a cycle has had a chance to occur.

 

Are you denying that mumbo and jumbo factors are contributory factors in all illness? Simon is not happy.

 

I have to say, there are very good chances that I adopt biopsychomumbojumbo from now on. It really rolls perfectly on the mind tongue. Sometimes words just align perfectly, even made-up ones. Although to be fair, all words are made-up.