Specialized cutaneous Schwann cells initiate pain sensation (August 2019), Ernfors, et al

Apparently, significant research in the field of allodynia. Here is a nice write up about the study, including comments by some prominent researchers in the field.

https://www.painresearchforum.org/news/126263-pain-nerve-endings-“bare”-no-more

here is the study abstract:

https://www.ncbi.nlm.nih.gov/pubmed/31416963

it is available on Sci-hub.

 

here is a quote in The Scientist article from Frank Rice, long time researcher in the field of touch and allodynia...

....Although the Schwann cells had been spotted before, Rice said, “they were not part of the thought process” when it comes to studying pain transduction. “We get locked into thinking about more traditional mechanisms. But they did the right experiments,” thanks in part to new technology such as genetic labeling and optogenetics. “When you have the right tools, suddenly the pieces start coming together. And now we have evidence that these cells are important players in pain mechanisms—it’s going to be a game changer.”......

 

aha