pain

Perioperative outcomes in myalgic encephalomyelitis/chronic fatigue syndrome undergoing general anesthesia: a retrospective matched-pair study BACKGROUND Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disease characterized by profound fatigue...

Until a few days ago, I did not know this award existed. I found this description of the co-winners of the prize. work to be interesting and a worthwhile read. This is one area where mouse models have contributed towards advancing the understanding of the human physiology. The complexity of...

Key Points Question Is transcutaneous electrical nerve stimulation (TENS) effective for treating pain when combined with physical therapy (PT) in individuals with fibromyalgia? Findings This cluster randomized clinical trial of 459 participants with fibromyalgia from 28 PT clinics from 6...

I am thankful I do not live in Spain. //////////////////////////////////////// Beliefs, attitudes, knowledge, and behaviours of physical therapists towards pediatric complex regional pain syndrome, 2026, Moutafakir et al Beliefs, attitudes, knowledge, and behaviours of physical therapists...

Multicenter randomized controlled trial of cognitive-behavioral, exercise-based, and combined interventions for juvenile fibromyalgia Abstract Abstract Juvenile fibromyalgia (JFM) is a complex and disabling chronic pain condition for which treatment options are limited. The objective of this...

Peak alpha frequency is associated with pain severity in Long COVID patients with new-onset chronic pain New-onset chronic pain is a common and debilitating symptom of Long COVID (LC) that remains not fully understood in terms of pathophysiology and therapeutic targets. A growing body of...

A cellular basis for heightened gut sensitivity in females Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fibers likely contributes to this sex...

Associations Between Genetic Polymorphisms and Psychological Variables in Women With Fibromyalgia: A Cross‐Sectional Study, 2025, Riquelme‐Aguado et al. ABSTRACT Introduction Fibromyalgia (FM) is a multifactorial syndrome involving chronic pain and psychological distress. Psychological traits...

Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to...

Tulane University: "Tulane scientists uncover new pain-signaling switch" 'Researchers found that nerve cells communicate outside the cell with the enzyme vertebrate lonesome kinase (VLK), which can alter proteins in the space between neurons, affecting how those cells send signals. “This is...

Abstract This study aims to evaluate the impact of pain catastrophizing (PC) on disease activity in patients with rheumatoid arthritis (RA) and to explore, in the same participants, if this association is related or not with anxiety and depression, which have been related to catastrophization in...

I am still reading this… this is a very good summary by some leading researchers about the difficulties they have encountered in trying to develop non-opioid painkillers using the sodium channel Nav1.8. It’s been a difficult and perplexing process and there’s an immense amount of pressure to...

Can I ask if anyone has been given morphine to help with their dire pain and malaise. I’m taking codeine and pregablin plus duloxetine and nortriptyline. But I’m in dire agony now nearly all of the time. I’ve had a small bit of a friends morphine which helped me immensely but as yet cannot get...

Hormonal Fluctuations and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Women: The Role of Menstrual Cycle and Menopause Mehak Khan, Sidra Anees, Muhammad Muthar Anees, Komal Khalid Chaudhry, Syeda Marium Rashid Zaidi, Vishan Das, Rimal Rashid [Line breaks added] Abstract Myalgic...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 17 Chr17 contained one Tier 1 gene. **************** CA10 (Tier 1) • Protein: Carbonic anhydrase-related protein 10. UniProt. GeneCards. Note that this gene encodes a protein that lacks catalytic activity. The allele...

Pain among US adults before, during, and after the COVID-19 pandemic: a study using the 2019 to 2023 National Health Interview Survey Zajacova, Anna; Grol-Prokopczyk, Hanna; Nahin, Richard L The unprecedented disruption of the COVID-19 pandemic raises crucial questions about its impact on...

Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging The skull bone marrow is emerging as a critical hub for neuroimmune signaling in various disorders, with the potential to reshape how we understand brain-immune interactions. However, its role in...

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan Abstract Objectives: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...