The really interesting thing about the "cleaning cycle" discovery is that no one has checked for it before in people with neurological symptoms. Maybe CSF flow isn't a part of ME or LC, but we can't be sure if no one has bothered to look. It's also a brief intermittent effect, so it needs 24 hr/day monitoring while the subject does different activities. Well, there could be a long-term abnormality compared to controls, but again, has anyone looked? There are probably other subsystem functions that are yet to be discovered.
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses, 2019, Garber+
- Thread starter forestglip
- Start date
Jonathan Edwards
Senior Member (Voting Rights)
I think it may be worth checking whether it is real. It doesn't make a lot of sense in terms of what i know about fluid flux and physiologists constantly get these things wrong. Small molecular waste leaves by diffusion, not convective flow. Proteins can probably be scavenged by microglia. The pulses of fluid shift may be entirely epiphenomenal.
Maybe regarding brain waves helping fluid flow in the glymphatic system?
I agree. Is this a new discovery of something overlooked because it didn't have a dramatic effect, or a dramatic exaggeration of some data? The latter is all too common. Hopefully someone will try to verify the finding.
Hmmm, I suppose it's possible to have some effect such as this that doesn't exist in healthy people, but does occur in some people. For example, sleep deprivation might weaken some membrane allowing more diffusion, allowing more fluid to build up where it normally doesn't, which then gets pumped by pulses in some nearby vessel. The phenomenon would only occur in specific circumstances. Just thinking out loud here.