Teclistamab for ME/CFS

[rapidboson]

It seems as though Dr. Habets has successfully treated an ME patient with low doses teclistamab. Much more cost effective than daratumumab apparently (< 1000€ per treatment course). This is the German maverick oncologist that's also treated ME patients successfully with daratumumab in the past.

https://twitter.com/user/status/1925124231940989201


Teclistamab is a BCMA directed T-cell engager (i.e. it "tells" cytotoxic t cells to kill BCMA expressing cells). BCMA seems to be present on later stage B cells and long lived plasma cells.

Extremely early and just a clinical anecdote but interesting nonetheless.

Has anybody heard of this in the context of ME before?

 

[EndME]

I've seen Habets posting that he has treated patients with pretty much anything. Unfortunately his posts also tend to be full with nonsense.

In the post following this one he write: "that is clear you have to remove the spikes with maraviroc, testing spikes in white blood cells and GPCR auto antibodies is standard diagnostics"

 

[Jaybee00]

Yes there is a lot of discussion of tecli in the auto immune forums I visit. But my friends say his dosage is probably too low.

 

[Jaybee00]

Tecli is definitely not a benign drug—dara much safer.

 

[Arfmeister]

Teclistamab is a BCMA directed T-cell engager (i.e. it "tells" cytotoxic t cells to kill BCMA expressing cells). BCMA seems to be present on later stage B cells and long lived plasma cells.

Yes, It's aiming at the long lived plasma cells and their precursor cells. With its bi-specific properties it's not only aiming at BCMA but also CD3 T-Cells.
- That makes it more potent than Dara
- it directly uses parts of the own immune system to clear cells
- It goes deeper in tissue and is expected to be more effective in depletion of AAbs than Daratumumab for example

With auto-immune diseases much higher dosages are used, so this is low dosage

Tecli is definitely not a benign drug—dara much safer.

The higher dosage have indeed higher risks - than Dara

 

[rapidboson]

I've seen Habets posting that he has treated patients with pretty much anything. Unfortunately his posts also tend to be full with nonsense.

In the post following this one he write: "that is clear you have to remove the spikes with maraviroc, testing spikes in white blood cells and GPCR auto antibodies is standard diagnostics"

Yeah, no idea what that is supposed to mean!

With its bi-specific properties it's not only aiming at BCMA but also CD3 T-Cells.

Yes, the "T-cell engager" part I mention in my first post is referring to the CD3 part
I can't speak for anything else you said regarding safety, potency or tissue penetration. I haven't look into it.

 

[Hutan]

Teclistamab is a BCMA directed T-cell engager (i.e. it "tells" cytotoxic t cells to kill BCMA expressing cells). BCMA seems to be present on later stage B cells and long lived plasma cells.

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.

TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).