I almost stopped reading here: "Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), was first reported in 1988" but skimmed through the rest. A review of existing cytokine studies, a bit muddled but not all bad. Looks a bit like a first attempt in the field. That impression is strengthened by this funding: "Grant-in-Aid for Young Scientists". So maybe any criticism should be directed at their mentors, and some encouragement to try again but do better at the young ones.