The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways, 2023, O'Connor et al.

Discussion in 'Other health news and research' started by SNT Gatchaman, Apr 2, 2023.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways
    O'Connor, Jennifer L.; Nissen, Jillian C.

    Microglia are the primary immunocompetent cells of the central nervous system (CNS). Their ability to survey, assess and respond to perturbations in their local environment is critical in their role of maintaining CNS homeostasis in health and disease. Microglia also have the capability of functioning in a heterogeneous manner depending on the nature of their local cues, as they can become activated on a spectrum from pro-inflammatory neurotoxic responses to anti-inflammatory protective responses.

    This review seeks to define the developmental and environmental cues that support microglial polarization towards these phenotypes, as well as discuss sexually dimorphic factors that can influence this process.

    Further, we describe a variety of CNS disorders including autoimmune disease, infection, and cancer that demonstrate disparities in disease severity or diagnosis rates between males and females, and posit that microglial sexual dimorphism underlies these differences.

    Understanding the mechanism behind differential CNS disease outcomes between men and women is crucial in the development of more effective targeted therapies.

    Link | PDF (International Journal of Molecular Sciences)
     
    Mij, CRG, Peter Trewhitt and 4 others like this.
  2. Madbeggar

    Madbeggar Established Member (Voting Rights)

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    Wait - I developed ME from exploring sexually dimorphic pathways?

    I thought that's what university was for!
     

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