Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development, 2026, Chhan et al

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Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development​

Highlights​

• Transgenic mice were used to make genetically human EBV mAbs against gp350 and gp42
• mAbs potently neutralize EBV infection by blocking receptor-ligand interactions
• mAbs prevent EBV infection following EBV challenge in humanized mice

Summary​

Epstein-Barr virus (EBV) causes infectious mononucleosis and contributes to neurodegenerative disorders and malignancies, particularly in immune-compromised hosts. Transplant patients face high risk of post-transplant lymphoproliferative disease, a life-threatening EBV-driven lymphoma. There are no EBV-specific vaccines or treatments; however, neutralizing antibodies against EBV glycoproteins may offer utility as therapeutic agents. EBV entry into B cells involves gp350, which binds complement receptors, and gp42, which engages HLA class II to trigger fusion. Most existing monoclonal antibodies (mAbs) against these antigens are non-human, limiting clinical use. Using a transgenic mouse model, we generate two gp350 and eight gp42 genetically human neutralizing mAbs that block receptor binding. Structural analyses reveal extended sites of vulnerability relevant to vaccine development. Delivery of a gp42 mAb protects humanized mice from EBV challenge, while a gp350 mAb provides partial protection. These mAbs highlight the utility of transgenic mice to produce therapeutic mAbs for preventing EBV-driven disease.

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00035-2

 

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Scientists Develop New Antibody For Virus That Infects 95% of People

The Epstein-Barr virus (EBV) is one of the world's most common viruses, thought to be lurking in 95 percent of adults.

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