UK Invest in ME conference 2025

Dr Systrom talk starting at 11:41 is very interesting. Preliminary partial data showing reduced mitochondrial biomass in muscle and / or reduced electron transport chain in some with ME/CFS. This is related to the reduced oxygen uptake see on the CPET test in a subset. Preliminary data, study still in progress.



Video is only showing 3 views! Come on guys, this is interesting.
 
Dr Systrom talk starting at 11:41 is very interesting. Preliminary partial data showing reduced mitochondrial biomass in muscle and / or reduced electron transport chain in some with ME/CFS. This is related to the reduced oxygen uptake see on the CPET test in a subset. Preliminary data, study still in progress.



Video is only showing 3 views! Come on guys, this is interesting.

Compared to activity-controlled healthy subjects?
 
Come on guys, this is interesting.

Systrom —

Mitochondrial biomass is down in all. (This is opposite to genetic primary mitochondrial myopathies where biomass increases to compensate.) Then you have two subsets: high systemic O2 extractors and low systemic O2 extractors (at peak exercise). Predicated on unimpaired or impaired electron transport chain. Do not know why or if the unimpaired also represents some degree of compensatory response.

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This is from preliminary baseline data. The post exercise challenge data should show more.
 
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In an interview Systrom showed a video of a participant step on step of as challange. Causing a "little PEM" he says.
It would certainly get me to PEM. I could not do that in the same tempo. That's why I am a Turtle.
 
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