USA: Center for Solutions for ME/CFS - news and updates from Columbia University's NIH funded center

I wonder on what basis? I don't remember him coming up with any findings, let alone anything that would point to particular drugs, but maybe I just haven't been following the work closely enough.

 

From what I know, IL-17 is the cytokine released by TH17 cells that recruits neurophils to sites of infection. Can you say a bit more about why it might be useful?

 

No comprendo “another thing”.

 

I guess I’m saying I like it when researchers explicitly state which specific drugs they recommend for trials (even if they end up being wrong). In most of these papers I see a lot of handwaving or very vague recommendations like “anti-inflammatories”, etc.

 

Will you be mentioning the [an]other thing in your upcoming paper?

 

IL-17 is a T cell derived cytokine that probably does lots of things. It seems to be involved in seronegative spondarthropathies which for me are the closest analogy I can think for what might be going on in ME/CF immunology. I don't have any more specific justification than that but at least it is about as logical as using rituximab if you think antibodies cells are involved.

I mentioned it Lipkin because he has given a presentation that mentioned IL-17 levels in ME/CFS. I seem to remember that Mady Hornig found a difference. I think the justification was moot but I would probably put it ahead of a lot of other things. IL-17 blockers have been used in other conditions and seem fairly safe.

 

Funny you should say that.

 

What are the chances of the non-biologists among us understanding your paper? Wondering if you could maybe write a very top-level summary of the key ideas that ordinary PwME could understand that S4ME or others could put out on social media, especially as it's likely that your paper will get a lot of attention, particularly once you put it up on Queios.

It would be better if you could provide a lay summary rather than random people making a hash of it and circulating a duff version.

Very excited about this paper! Can't wait!

 

You should be able to understand it.

 

That's very surprising!

 

Reposting @Dakota15 post on USA news thread. This may be a chance for folks to ask questions they have about Ian Lipkin's teams research. Takes place 6pm UK time on 9th April 2025.