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Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Discussion in 'BioMedical ME/CFS Research' started by Sly Saint, Apr 13, 2018.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection
    • Alice M. RichardsonEmail author,
    • Don P. Lewis,
    • Badia Kita,
    • Helen Ludlow,
    • Nigel P. Groome,
    • Mark P. Hedger,
    • David M. de Kretser and
    • Brett A. Lidbury
    Journal of Translational Medicine201816:97
    https://doi.org/10.1186/s12967-018-1473-z

    © The Author(s) 2018

    Received: 26 October 2017

    Accepted: 5 April 2018

    Published: 12 April 2018
    Uses another proxy 'WST'.
    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1473-z
     
    Michelle, MEMarge, ahimsa and 9 others like this.
  2. BruceInOz

    BruceInOz Senior Member (Voting Rights)

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    I'd have thought a comparison group of patients with orthostatic intolerance but NOT ME would have been essential. Not everyone with ME has OI.
     
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  3. Londinium

    Londinium Senior Member (Voting Rights)

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    Last edited: Apr 14, 2018
  4. Since2010

    Since2010 Established Member

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    @Londinium: This is the same team who found that Activin B was potential biomarker for ME. I believe the standing test findings and the Activin B findings were from the same patient cohort.

    I was in the replication Activin B/standing test study in 2016-17. Don't know how it went or when it'll be published - because (unlike certain BPS research teams ) this team has ethics and doesn't tell participants how studies are going until they're published.
     
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  5. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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    They looked at diagnostic criteria, though I don't fully understand what the percentages represent at the moment.
    Richardson 2018 Table 1.JPG
     
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