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I suspect they use multiple LLM AI agents when working on such complex problems, with some AIs coordinating tasks and others trying out different options and possibilities. So in a sense it doesn't matter that some AI answers are really stupid, they are probably reviewed by other AI bots and...

I did an attempt at doing a colocalization analysis between this fibromyalgia GWAS and DecodeME. Took significant hits from both GWAS and then checked if the other had a similar signal. This is done using the coloc package in R which assumes only 1 causal SNP. The downside is that this often...

Found some more support for this in this preprint (Ji et al. 2025) Benchmarking genome-wide association study causal gene prioritization for drug discovery They looked at genetic evidence leading to successful drug development. Distance (the nearest gene method) did equally well compared to...

They are in large part determined by distance but the folding can change that distance. We have looked at tools like H-MAGMA that try to incorporate that. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles |...

Can only add that this paper (like their previous one) raises all sorts of red flags for me. There's a lot of (justified) enthusiasm for genetic findings in ME/CFS but this isn't line of research isn't part of it. The media attention is mostly driven by commercial interests, rather than the...

The name dys-autonomia suggests these patients have a defect in the autonomous nervous system which we don't know yet.

Looks like the VADYS-ME study found something similar: https://s4me.info/threads/investigations-of-vascular-dysfunction-and-hypoperfusion-in-patients-diagnosed-with-me-cfs-vadys-me-2027-d%C3%B6hner-et-al.51494/post-716581

I wrote a brief blog article on the buspirone findings to help highlight the findings. It links to this S4ME discussion and the excellent overview by forestglip. https://mecfsscience.org/increased-prolactin-response-to-buspirone/

Well-deserved recognition for an impressive person.

Excellent work! The group tags probably aren't that important. The main thing to note is that several studies were students from working under Behan as your review already does.

Too poor to buy online access to the conference but would be interested in hearing more about this presentation:

I calculated an effect size (Hedges g) using the data in the thesis. Males Using prolactin values after 1 hour -1.38 [-2.42, -0.30] Using prolactin difference between baseline and 1 hour - 1.45 [-2.51, -0.36] Females Using prolactin values after 1 hour -1.71 [-2.96, -0.40] Using prolactin...

Yes that might be the more conservative option. The plot does show 15-minute intervals before the administration of buspirone. And as ScoutB says, the growth hormone plot also shows the same intervals up unto 240 so perhaps it's simply a bad description in the methods section.

Thanks, I've updated the plot accordingly.

I've been extracting the data from the graphs in the buspirone studies, it looks something like this. For Bakheit 1992 I took males only, Sharpe 1996 is also males only, the other studies have both sexes combined. EDIT: there might be an error in the Sharpe 1996 original data plot, see the...

I think the Sharpe 1996 (Cowen group) study had a pretty good view on the problem saying it was likely the dopamine instead of serotonin pathway that was abnormal. They wrote: Increased prolactin response to buspirone in chronic fatigue syndrome - PubMed My guess is that buspirone was seen as...

I have the CIBA symposium book from 1993 but it doesn't have much discussion on the buspirone tests. Doesn't work to upload the doc but here are some screenshot of the places where buspirone or prolactin is mentioned, the discussion moves to other topic afterwards. First section: Then a bit...

Yeah maybe the dopamine system in ME/CFS is less responsive so that those natural stimuli that reduce it centrally have less impact and thus we see a blunted prolactin response. But when you don't impact the dopamine system itself but simply block the dopamine that's already there, we see an...

There are a couple of studies that tried to block the serotonin route of buspirone and measure what effect it had on its prolactin effect. This 2001 study found that approximately 50% of its effect on prolactin disappeared when participants are first given the 5-HT1A antagonist pindolol. So...

Your little review was probably the most interesting paper I read on ME/CFS in 2026! Hope you can rest well and recover.