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@Jonathan Edwards would be interested in hearing your views about this, especially regarding whether AI has true intelligence, understanding, and insight. Also, with your expertise in research on consciousness, do you think AI models already have consciousness, that they will get it in the...

I think most of the world doesn't see this yet, because you have to have one foot inside programming or math to really understand how powerful AI is at the moment. Most people's experience of AI is asking it a question instead of googling it - so a single agent, on a free version, not the...

Not so sure about this because, in essence, it comes down to how much one can extrapolate from the data we collect. How many more scientific rules and principles can an AI distill from those than us? I guess that it's likely a lot. Perhaps the AI will be able to predict those novel...

I thought that Dibble (T-cell repertoires) and Ryback (B-cell repertoires) already did this, but without clear results.

Thanks, although I already had the impression that DCC is one of those long genes that shows up in a lot of places.

I'm not so sure, suspect we're almost at the point where AI (the top models like Claude Fable or GPT-6-Astra) is better and faster at coding than almost all human coders. I don't have a coding background though, so perhaps others can provide more insight. It seems to have already have made an...

Feel free to share more insight from the mathematics community because it feels like insight/warning about what's going to happen in many other fields. The coding community is similarly affected but it has many people wanting to hype AI because of commercial interests, so I feel like the...

I suspect they use multiple LLM AI agents when working on such complex problems, with some AIs coordinating tasks and others trying out different options and possibilities. So in a sense it doesn't matter that some AI answers are really stupid, they are probably reviewed by other AI bots and...

I did an attempt at doing a colocalization analysis between this fibromyalgia GWAS and DecodeME. Took significant hits from both GWAS and then checked if the other had a similar signal. This is done using the coloc package in R which assumes only 1 causal SNP. The downside is that this often...

Found some more support for this in this preprint (Ji et al. 2025) Benchmarking genome-wide association study causal gene prioritization for drug discovery They looked at genetic evidence leading to successful drug development. Distance (the nearest gene method) did equally well compared to...

They are in large part determined by distance but the folding can change that distance. We have looked at tools like H-MAGMA that try to incorporate that. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles |...

Can only add that this paper (like their previous one) raises all sorts of red flags for me. There's a lot of (justified) enthusiasm for genetic findings in ME/CFS but this isn't line of research isn't part of it. The media attention is mostly driven by commercial interests, rather than the...

The name dys-autonomia suggests these patients have a defect in the autonomous nervous system which we don't know yet.

Looks like the VADYS-ME study found something similar: https://s4me.info/threads/investigations-of-vascular-dysfunction-and-hypoperfusion-in-patients-diagnosed-with-me-cfs-vadys-me-2027-d%C3%B6hner-et-al.51494/post-716581

I wrote a brief blog article on the buspirone findings to help highlight the findings. It links to this S4ME discussion and the excellent overview by forestglip. https://mecfsscience.org/increased-prolactin-response-to-buspirone/

Well-deserved recognition for an impressive person.

Excellent work! The group tags probably aren't that important. The main thing to note is that several studies were students from working under Behan as your review already does.

Too poor to buy online access to the conference but would be interested in hearing more about this presentation:

I calculated an effect size (Hedges g) using the data in the thesis. Males Using prolactin values after 1 hour -1.38 [-2.42, -0.30] Using prolactin difference between baseline and 1 hour - 1.45 [-2.51, -0.36] Females Using prolactin values after 1 hour -1.71 [-2.96, -0.40] Using prolactin...

Yes that might be the more conservative option. The plot does show 15-minute intervals before the administration of buspirone. And as ScoutB says, the growth hormone plot also shows the same intervals up unto 240 so perhaps it's simply a bad description in the methods section.