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It sounds like something similar the OMF Melbourne study is doing - although not to the length and extent you propose.

Biopsy studies, I used to be interest in what a brain biopsy would show but I wonder if that's really useful if the illness is a signalling problem. I know Hartford OMF planned muscle biopsies (who knows how far along this is). I'm not sure how useful these would be anymore.

MEEPs? I don't know that word. Interesting to read, the illness seemed to hit at the two peaks discussed on this forum - mid-late teens and early-mid thirties. I would have to think a geneticist studying the disease must be interested in a family in which 4! persons have this illness severely...

Interesting Reddit thread on Abilify today - Seeing again mentions of modest, non curative, improvement from 2 users, and tolerance or a loss of improvement from a second user. A third user again mentions the Abilify/Celebrex combination, which has been suggested to reduce or prevent tolerance...

Makes total sense. He has a wonderful voice for pbs, I may watch some of his videos on his website. @Tom Kindlon It was a lovely piece, and it does take courage to put yourself out there. I think you handled everything with class and clarity.

I'd have to agree with you. Jonathan Edwards has spoken about the labelling of it as "complex, multi-system disease" as being kinda of a misnomer (I don't want to speak for him but that was my understanding). Difficult to find, yes. But, it's there, in all it's pieces, patiently waiting to be...

I've always wondered who is Llewellyn King and who did he become involved in me/cfs? edit: corrected my mispelling of his first name

There have been several reports of Celebrex taken with Abilify, supposedly for a synergistic purpose. It may be worth conducting a study on Celebrex for symptom relief in me/cfs as well. I noted a while ago, Pridgen was studying this with an antiviral in Fibro with poorly controlled studies...

Also, not sure if this is the right thread, or maybe there is an OMF thread, but these tweets suggest a PET study has been completed on neuroinflammation in me/cfs from the James Lab at Stanford. Hopefully, it will be published soon. https://twitter.com/i/web/status/1290691765867966465

I don't know if this is the right thread to post it or if there is a general OMF Trials thread, but in Cort's blog he mentioned they will also conduct a trial with Abilify. So, I believe that's 4 trials (Abilify, kynurenine, mestinon and Chris Amrstrong's study).

The question becomes, if bonilla (sp?) found a patient improved taking it for some other reason, how did it get to a low-dose therapy? And what is low dose doing that higher doses aren't or might a higher dose be better? I'm not sure the second part is worth asking at this point, and it's good...

Amongst antipsychotics abilify has the lowest or one of the lowest weight gain profiles. Google or google scholar should show you some results. This may be due to it's unique mechanism of action. For example, it doesn't impact histamine receptors and increase AMPK which was one factor associated...

It may be that in Whitney, the Abilify is reducing his severe gastroparesis and I can only imagine the effects that has on the body as whole, including brain fog and fatigue. I don't know about your other reference's response. Wikipedia has a good review of it's actions in the brain, it is a...

The most important condition with regards to modern psychosomatic illness is not me/cfs but non-epileptic seizure. This is a seizure without the electrical activity in the brain associated with a seizure when it occurs. Followed would be functional movement disorder. The proof here is assumed...

I won't be able to read this today, but if it is what I hope it is, I will be pleased for the reasons @rvallee mentioned. Furthermore, I believe it is the first study published by Nath and the inhouse study. Characterizing the defining feature of me/cfs from a well regarded institution and a...

@Michiel Tack It is possible that the "rocking-bed" study https://projectreporter.nih.gov/project_info_description.cfm?projectnumber=1R21NS108094-01A1 may lead to a study on it as a treatment for sleep disturbance in me/cfs or me/cfs with fm, depending on the results of the first study. Of...

I think this is very likely to be the case. The patient "survery/study" was interesting. I understand the desire to be inclusive, and this is patient driven, but if your trying to establish the characteristics of post-covid, having only 1/4 who you can be 100% sure had covid makes it...

I have read a few studies now on adult tethered cord (although none on adult occult tethered cord, if you wan to link some I will gladly read them). I don't claim to be an expert on any of this, just giving it my best shot. The main symptoms seem to be leg/back pain and urinary urgency and...

Thanks. Why do you think you have occult tethered cord? It's one of dx's we've heard about that seems less controversial, persumably because it's a less risky or serious surgery (what one dr has told me) and the end result isn't a fixation of the neck. I have only read one slide show on it - by...

Thank you for sharing, may I ask what your fusion was intended for, if not CCI?