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Yes, I'm only referring to the phase 2 trial, and assuming the phase 3 trial was underpowered to replicate the effect. But it does make more sense that cyclo would be the drug with the common mechanism, since it was the one that started this whole thing.

Oh yeah, I don't think there's any reason to care much about proving rituximab works with giant sample sizes. It clearly isn't very effective. I'm just saying that I think there is reason to believe that either cyclo or rituximab (or both) actually affects some mechanism that improves ME/CFS...

Right, if you have a booster. But if dara wiped out all LLPCs, would tetanus antibodies quickly be automatically re-made? If some wonky LLPCs got made when a person got a COVID infection and which cause ME/CFS, but without a persistent antigen, I wouldn't expect them to quickly be replaced if...

Can you link to something saying disulfiram depletes LLPCs? I can't see anything about that from a scan of those threads or a search.

Doesn't this replacement with new B cells require re-exposure to an antigen? I was thinking that the LLPCs are created originally for some reason, but that the antigen is long gone if it ever existed, since there aren't signs this is a typical autoimmune disease, so there'd be no reason for the...

I'll need to re-look at that. I might have misremembered the improvement being more impressive. Okay, if they're both just killing everything, that makes B cell specificity less convincing. Yes, I was going with the idea that higher efficacy is probably the explanation for the difference due...

I know discussions about how antibodies don't make sense have happened a million times probably but it's mostly been hard for me to understand. Can someone say why what seems to be simplest way to look at the results we see is not the most likely: that the mechanism of action of dara is due to...

Oh sorry you're right, I totally skipped over that both the MM studies in that thread are about bone marrow NK cells, not blood.

Oh yes sorry, just saw your post. Yes, that was incorrect to say it was the NIH study.

The Fluge paper looked at "CD16/56 positive NK cells" and found higher baseline levels correlate with recovery. From multiple myeloma paper: So they seem similar. I don't know the implication of the difference in the ME/CFS study also including CD56 though.

The way I always assumed it worked, though I could be wrong, is that the analysis finds relatively few harmful variants in the actual sample. If they found, say, that participants 1 and 2 have an LoF variant in DLGAP1 and participants 3 and 4 have an LoF variant in DLGAP2, then the machine...

In Article History, I don't see an update on September 6 (though I see the article does say that date for some reason), but it did get updated on July 10, 2025 to switch from describing some old criteria to describing IOM, so now post-exertional malaise is included. Maybe the September 6 update...

Farming Life: 'Cumbrian farmer features in unique photography exhibition highlighting ME/CFS' "The experiences of Cumbrian farmer, Andrew Jackson (58), who has lived with ME/CFS for more than 13 years, has been captured and displayed in an evocative photography exhibition at the iconic Oxo...

ME Association: Photo Exhibition: ‘Lives We Cannot Live’ by Jeremy Jeffs ‘Lives We Cannot Live’ is a ground-breaking new exhibition featuring photos and stories of people with ME/CFS by photographer Jeremy Jeffs, presented by the ME Association. It brings identity and visibility to the ME...

This is a re-analysis of the hand grip strength data from: Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al We have a thread specifically on the hand grip results here: Grip test results and brain imaging in the NIH study: Deep...

Variation in Repeated Handgrip Strength Testing Indicates Submaximal Force Production in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Stoyan Popkirov Background Changes in handgrip strength have recently been adapted as clinical biomarkers for myalgic...

“The rising cost of Long COVID and ME/CFS in Germany” – the interview on the study Video in German with English subtitles. The description:

Are they referring to something else when they say "small minority"? 63% is clearly not a minority. They refer to "documented" infection. Is there data on what proportion of these infections in DecodeME were "documented"?

In fact, 90% of points would be expected to be below a -log10 p-value of 1. If looking at the x-axis in the QQ-plot (the expected p-value for each point if it was a null distribution), 90% of points are left of 1 (p>0.1), 99% left of 2 (p>0.01), 99.9% left of 3 (p>0.001), and so on. I...

Yeah I was thinking that most of the photos they recommend just look like people sleeping. If it's hard for people in the life of a pwME to really know what's going on, then trying to capture it in a photo is nearly impossible.