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    News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

    Any statement by researchers which contributes to the phenomena of patients confidently stating unproven hypotheses as fact, further delegitmising them in the eyes of medics, is deeply irresponsible imo.
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    Closed UK: DecodeME updates, was recruitment thread.

    I think the rest of the community would have had a thing or two to say about that...:joy:
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    Closed UK: DecodeME updates, was recruitment thread.

    This is incredibly exciting! Thank you to the whole team! P.s. i picked the wrong week to move house :eek:
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    Teclistamab for ME/CFS

    Agreed. Hopefully if any theraputic experiments follow on from DecodeME they will include controls from the get go.
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    Teclistamab for ME/CFS

    Mella said so in his Charite talk this year.
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    New Swiss study probes lingering fatigue after Legionnaires' disease

    My definite (as opposed to possible prodromal) onset was after a dual strep and impetigo infection. Interestingly not the strain of strep that causes impetigo so two different infections. Point is bacterial infections definitely seem to be a trigger.
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    Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to [CFS] and Long COVID-19 sera, 2025, Mughal+

    The question is have they created PEM in a dish or found the factor that causes ME/CFS exercise intolerance and muscle weakness/fatiguability? As opposed to delayed PEM.
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    Review Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Komaroff et al.

    Precicely i feel like they are talking about something that isnt neuroinflammation. These new drugs they are talking about are intriguing but I don't find it particularly compelling as a hypothesis.
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    Review Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Komaroff et al.

    I don't feel like the authors provide any evidence that neuroinflammation is the cause. And also is the definition that its 'immune activation within the brain' accurate? But the idea of targeting the sickness behavior itself rather than the cause of it is kind of intriguing. I guess time will...
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    Review Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Komaroff et al.

    Does the idea that its caused by neuroinflammation and will need new anti-inflammatory drugs to treat carry weight with anyone round here? It sort of seems like a shrug type response to me...
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    News from the USA, United States of America

    Do we know if the DecodeME team will be attending?
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    What research do you want to see? (study ideas)

    Yeah this work is facinating and if it replicates it could be really important.
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    Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to [CFS] and Long COVID-19 sera, 2025, Mughal+

    What are the implications if this study replicates? If the factor in the serum causing these responses can be identified and removed, will cells and muscles return to normal? The paper calls these effects transient, so one would hope so... And would this finding gel or clash with the...
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    Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to [CFS] and Long COVID-19 sera, 2025, Mughal+

    What was the sample size here, out of curiosity?
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    USA: News from the Bateman Horne Center

    Yeah if I had a couple of weeks or a month I could maybe do something but 4 days is nowhere near enough time
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    UK: Medical Research Council: Centre to study how exposome causes chronic inflammatory disease

    This is a concern of mine too. I know JE and others are fairly confident there is going to be a sea change and I sincerely hope they are right, but I haven't seen concrete evidence of it yet. Perhaps we should brainstorm what we can do in the event government funding is not forthcoming. I think...
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    Trial Report Viral spike antigen clearance and augmented recovery in children with post-COVID [MIS-C] treated with larazotide, 2025, Yonker et al

    As someone who has had horrendous GI symptoms since covid at the end of 2020, I would be very interested to know if this bears out and also whether this drug is suitable for adults. Edit: Oh it's for MIS-C, I didn't clock that at first I thought general LC.
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    International ME/CFS Conference 2025 Berlin May 12-13

    I have just watched Tronstad's talk - I am wondering if his theories are linked with Fluge and Mella's B cell stuff or if they are separate hypothesis? They are part of the same research group if I'm not mistaken.
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    Open ReMEdi clinical trial, UK [Lindus Health, Alfred E. Tiefenbacher GmbH]

    Well that gives the opposite of confidence...
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    Research news from Bhupesh Prusty

    My memory is that his work didn't show anything beyond doubt, after he spend months encouraging everyone to board the biomarker hype train.
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