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The Canary: 'A groundbreaking documentary on ME/CFS is now available to international audiences' ---- 'The documentary has gone live to rent on Vimeo. The film is in German, but international viewers can select various subtitle options to follow it in their preferred language. However, if you...

Long-COVID is associated with increased absenteeism from work Jaewhan Kim, Sanghoon Lee, Peter Weir [Line breaks added] Abstract Long-COVID, defined as COVID-19 symptoms persisting for more than 3 months, may lead to persistent health issues requiring extensive medical care. Despite its...

I tried reading the paper, and can't understand most of it. But I think the main idea is this: they're not looking for SNPs that cause these conditions. They're looking for SNPs that cause increased variation in getting the condition (in other words, SNPs that increase the influence of...

Depression Anxiety Autistic traits Psychotic-like experiences

Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes Abstract Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic...

Amplification of select autonomous HERV loci and surrounding host gene transcription in monocytes from patients with post-acute sequelae of COVID-19 Hyunmin Koo, Casey D. Morrow [Line breaks added] Background The human genome contains approximately 3,200 near full-length autonomous human...

The Implications and Predictability of Sleep Reversal for People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Machine Learning Approach Meghan P. Dietrich, Raam Pravin, Jacob Furst, Leonard A. Jason Background/Objectives: Impaired sleep is one of the core symptoms of myalgic...

I can't find one from a quick search, but maybe an auto-translation of the relevant parts would be okay?

Interestingly, scyllo-inositol has been tested as a treatment for Alzheimer's, bipolar disorder, and down syndrome, with apparently negative results in all. (Wikipedia)

Forensic biomarker discovery: Utilising metabolomics to elucidate prospective fatigue biomarkers for eventual roadside detection Aaron Hamilton, Luke Whiley, Maria Kadyrov, Brendan Chapman Highlights • Metabolomics can be used to identify biomarkers for fatigue. • Scyllo-inositol...

Agree with other posters - very well written and thorough. I wonder if the diagnostic criteria might be a factor. CCC in Fluge et al, but CCC and/or IOM here, so maybe the factor in the blood wasn't necessarily related to ME/CFS, but was related to a comorbidity required by CCC but not by IOM.

Here's an association, but this specifically is only describing healthy controls. It's a positive correlation between Vitality (SF-36) and IGHV3-23/IGHV3-30. r=0.527, q=0.039. The more they have the healthier they are, so opposite direction of the association between controls and ME/CFS in the...

Wow I just put together that chillier is the one of the people from your 'something in the blood' post. The username makes sense now, I thought they were just cold. Someone asked if she falsified the nanoneedle study. She said it's hard to compare her result to Ron Davis's, but that Fatima...

The study status is now "Withdrawn - Company focus shifted".

Nature: "Science-integrity project will root out bad medical papers ‘and tell everyone’" ---- 'The Center for Scientific Integrity — the non-profit organization that runs Retraction Watch — has launched a project aimed at rounding up flawed and fake medical-research papers and neutralizing...

Now published: Link | PDF

Pathogen-specific exposure is associated with multisite chronic pain: A prospective cohort study Jialiu Fang, Zemene Demelash Kifle, Jing Tian, Silvana Bettiol, Flavia Cicuttini, Graeme Jones, Feng Pan [Line breaks added] Abstract Evidence suggests that pathogens may influence pain perception...

Deoxygenation Trends and Their Multivariate Association with Self-Reported Fatigue in Post-COVID Syndrome Anja-Maria Ladek, Marianna Lucio, Andreas Weiß, Thomas Knauer, Helena Sarmiento, Miriam Ilgner, Marie Jakobi, Laura Barteczko, Marion Ganslmayer, Jürgen Rech, Antonio Bergua, Christian Y...

Quote from another thread, but thought it'd be good to post this response here. I put the top 115 genes into STRING to see the connections between proteins. HLA-C only has evidence linking it to one other protein with medium confidence, PSMB5. The same graph in interactive form can be seen...

The search engine AIs are very bad with hallucinations, much worse than the stand-alone chatbots. I wouldn't ever trust the Google Search AI without checking its sources. I mean that's good practice with any AI, but I feel like with the search AIs it's basically a coin flip whether it just makes...