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@Adam pwme , just watching this again, it's so well done. Could you possibly update it when the new NICE guidelines come out?

One of the things that is interesting about this paper, is its view of chronic fatigue syndrome, and the suggestion that the condition didn't have a name for many years prior. There's a quote about the lack of attention fatigue has had, despite it being very debilitating. Which highlights...

An old paper, one that I found when I was looking for papers related to physiotherapy. https://www.researchgate.net/publication/233658666_Fatigue_-_concepts_for_physiotherapy_management_and_measurement Free Abstract

Personally, I'm more than happy for DMissa to weigh in. I am very grateful to the Fisher team for their interest in ME/CFS; their papers are always well written and the studies are interesting. Yes, it feels as though the mitochondrial research is still quite new, with more understanding yet...

She may be playing tricks, but with 'more participants having perforated appendicitis than anticipated', I expect this feasibility trial will be put to one side and there will be another roll of the dice for the main trial. Cheaper for the health system/insurers than an operation no doubt, but...

There wasn't much in the cytokine analysis, in terms of differentiating post-Covid participants with (nCov) and without (Cov) neurological symptoms. I thought the IgG levels measured was interesting - these are in confirmed cases of Covid-19, with some of them having no or very low antibodies...

The premise is really interesting. It seems that they can isolate particular extracellular vesicles using antibodies against a cell adhesion molecule that is expressed on neurons. I'm not quite sure if that means that the vesicles with the neuronal cell adhesion molecule have come from neuron...

Yes, I do remember that, and was convinced by it. But I have heard other Australian mitochondrial researchers be very dismissive of the idea of using lymphoblasts to investigate ME/CFS - they feel that the cells will be too different from cells taken fresh from the body. When I mentioned the...

(I haven't read this study) What's the bet that the nineteen studies were retrospective, with all the bias in reporting that that implies. And, even if it is true that a higher risk of abuse correlates with a higher risk of fibromyalgia, it's correlation, not causation. A higher risk of...

But they still used immortalisation to make lymphoblasts. They do cite the Sweetman paper though, that used lymphocytes and found similar things.

Do all the researchers use lymphocytes/lymphoblasts because they think cells involved in immunity are going to tell us something that other body cells cannot? Or is it just because it's relatively easy to get hold of samples? Is there any risk of the 'Drunk looking for his keys under the...

So, if those differences are there between ME/CFS and controls, in both non-immortalised PBMCs and lymphoblasts, what does that tell us about what is causing the differences? The lymphoblasts will have been frozen, and presumably washed, and cultured, and treated with the EBV, umm, treatment...

A really nice background - it can be hard to get it right, but this one nails it, I think. Background Page 3 typo

@DMissa, nice to see another paper out. What is up next for you and the team? Do you have funding?

From Emerge's 'Lessons Learned from the Health and Wellbeing Survey of Australians Living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 2019': https://www.emerge.org.au/Handlers/Download.ashx?IDMF=609ff625-4eb0-4f5f-b1af-782d08e2b61f The most common support provided was...

On the one hand we are told to increase our self-compassion, and redefine recovery as acceptance of limited lives (and stop bothering the medical system). On the other hand, we are told to increase our self-management skills to work towards recovery by pushing beyond our moral and physical...

yes I did

Reference 105: Cox, B.S.; Alharshawi, K.; Lafuse, W.P.; Ariza, M.E. Herpesvirus dUTPases contribute to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by promoting follicular helper T cell differentiation. JCI 2021. Submitted. Potentially relevant to the reported finding of higher numbers of...

Here's the thread on the 2017 paper: ME/CFS and gulf war illness patients exhibit increased humoral responses to herpesviruses-encoded dUTP, 2017, Halpin, Klimas, Fletcher et al

Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology Peter Halpin 1, Marshall Vance Williams 1 2, Nancy G Klimas 3 4, Mary Ann Fletcher 3 4, Zachary...