Search results

Thanks @Dolphin

Did White say this? Thought this mainly came from the CBT psychiatrists like Sharpe and Van Houdenhove.

Looks like this is from Vincent Lombardi's NIH grant with more info here: https://reporter.nih.gov/search/ngGdmGN8a0u3XJm2ZsBoow/project-details/11085301

This seems to be the main idea but not seems highly doubtful if this will work

Incredible, the story is heartbreaking.

Ah, so the h^2 pedigree in the Wainschtein et al. (2025) paper already used the lower heritability estimates using those algorithms, not the high estimates from twin and kin studies?

Counterpoint is this recent paper in Nature, which suggests that we simply need bigger sample sizes and more detailed measurements of all SNPs, including rare ones. Estimation and mapping of the missing heritability of human phenotypes | Nature

I thought they compared identical with non-identical twins, so that environmental confounders are substracted (as they are present in both pairs of twins).

Some weird sentences:

Another increasing issue is AI-created summaries on social media. Researchers often oversell their findings in the paper, and it seems that AI then inflates this even further. Don't have an issue with using AI per se (it can be useful in many situations), but the LLMs people use don't think...

Researchers from the University of Vienna are developing a new PEM questionnaire. https://www.soscisurvey.de/V-PEM-AQ_english/ Shared by Rob Wust on Twitter:

Probably not much to see here. The study has a small sample size (27 LC patients) and the authors measured mitochondrial mass and membrane potential in 9 different immune cell types. That's 18 different comparisons, and it looks as if no correction was done for multiple testing. So it should...

Some questions were raised about the NHIS survey data in this thread: https://www.s4me.info/threads/cdc-data-brief-myalgic-encephalomyelitis-chronic-fatigue-syndrome-in-adults-united-states-2021%E2%80%932022-2023-vahratian-unger-et-al.36480/post-566066 In the 2023 NHIS survey, the prevalence of...

"The authors declare no competing interests." Jeff Wood's website: "I now work as a consultant to chronically ill patients, as well as to researchers and MDs who serve the chronically ill community." https://www.explorewithjeff.com/

See what you mean. They show that lupus patients have an increased number of these EBV-infected B cells, that these are reprogrammed, for example, to remain active, and present antigens, that they respond to antinuclear antigens, and that they can activate T-cells. But the smoking seems to be...

Sounds interesting, anyone able to share a copy?

Great news! I wonder what they mean with post-infectious disease: is it ME/CFS and Long Covid, or other diseases as well?

Looks like this is just based on self-reported questionnaires. Don't think one can study MCAS by just asking patients if they report certain symptoms or responses to treatment.

Here's the link to that previous study: Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients - ScienceDirect Looks like in other disorders such as schizophrenia, reeling has mostly been found to be...

Should we have a closer look at reelin? Both the blood marker and gene expression were increased in patients. This team has reported this before in LC. Here's the wikipedia description: