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Yes, feeling terribly awful so that nobody in such condition would be able to ride a Tour stage. The more similar to ME/CFS the better. Which immune responses cause sickness behavior and which don't is interesting, but a different question from the one I wanted to ask. Namely, if there are...

Thanks for the responses. I was mainly thinking about an antiviral immune response that makes most people very sick and fatigued, but in some exceptions, don't cause any symptoms at all. So localised immune activation in the gut or eczema wouldn't count. The main idea is: if sickness...

Was wondering if there is any medical condition where the immune response works normally (for example, in response to an infection) but where patients don't feel ill with fatigue and malaise. In other words, an immune response without sickness behavior. It could be like the opposite of ME/CFS.

Thanks @Ferry, that quote is really clear.

Looks like it was very well done, professionally organized, nice turnout, moving speeches, and lots of national press coverage. Kudos to the organizers and everyone who participated. EDIT: screenshot from the livestream:

Thanks @Dolphin

Did White say this? Thought this mainly came from the CBT psychiatrists like Sharpe and Van Houdenhove.

Looks like this is from Vincent Lombardi's NIH grant with more info here: https://reporter.nih.gov/search/ngGdmGN8a0u3XJm2ZsBoow/project-details/11085301

This seems to be the main idea but not seems highly doubtful if this will work

Incredible, the story is heartbreaking.

Ah, so the h^2 pedigree in the Wainschtein et al. (2025) paper already used the lower heritability estimates using those algorithms, not the high estimates from twin and kin studies?

Counterpoint is this recent paper in Nature, which suggests that we simply need bigger sample sizes and more detailed measurements of all SNPs, including rare ones. Estimation and mapping of the missing heritability of human phenotypes | Nature

I thought they compared identical with non-identical twins, so that environmental confounders are substracted (as they are present in both pairs of twins).

Some weird sentences:

Another increasing issue is AI-created summaries on social media. Researchers often oversell their findings in the paper, and it seems that AI then inflates this even further. Don't have an issue with using AI per se (it can be useful in many situations), but the LLMs people use don't think...

Researchers from the University of Vienna are developing a new PEM questionnaire. https://www.soscisurvey.de/V-PEM-AQ_english/ Shared by Rob Wust on Twitter:

Probably not much to see here. The study has a small sample size (27 LC patients) and the authors measured mitochondrial mass and membrane potential in 9 different immune cell types. That's 18 different comparisons, and it looks as if no correction was done for multiple testing. So it should...

Some questions were raised about the NHIS survey data in this thread: https://www.s4me.info/threads/cdc-data-brief-myalgic-encephalomyelitis-chronic-fatigue-syndrome-in-adults-united-states-2021%E2%80%932022-2023-vahratian-unger-et-al.36480/post-566066 In the 2023 NHIS survey, the prevalence of...

"The authors declare no competing interests." Jeff Wood's website: "I now work as a consultant to chronically ill patients, as well as to researchers and MDs who serve the chronically ill community." https://www.explorewithjeff.com/

See what you mean. They show that lupus patients have an increased number of these EBV-infected B cells, that these are reprogrammed, for example, to remain active, and present antigens, that they respond to antinuclear antigens, and that they can activate T-cells. But the smoking seems to be...