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  1. James

    Activity pacing: moving beyond taking breaks and slowing down (Antcliff et al. 2018)

    This rebranding of pacing as APT where it was used as a straw man in the PACE trial and would therefore be less effective than the predetermined outcome for CBT (Constant Bullsh*t Treatment) and GET (Gradual Euthanasia Therapy) is indeed strange as the bio psych mob have already discredited...
  2. James

    PACE trial data

    David Tuller had asked for the raw data December 2015 http://www.virology.ws/2015/12/17/a-request-for-data-from-the-pace-trial/
  3. James

    PACE trial data

    Could they just box up the raw data that no staff employed at QMUL can read and must be taking up space in a spring cleaning exercise for the university o_O
  4. James

    PACE Trial application to MRC for funding in 2002

    Cannot find any mention of the confidentiality clause QMUL apply when not allowing anonymised data out, such as is currently used when denying access - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040808
  5. James

    Blood clotting disorders and ME

    Could oxidative stress that triggers hemoglobin production combined with the lower blood volumes (Bell - Streeten) be a biological adaption as the body moves towards using anaerobic energy production. https://www2.palomar.edu/anthro/adapt/adapt_3.htm
  6. James

    PACE Trial application to MRC for funding in 2002

    I was not on the ship, neither as passenger or crew. I helped recruit some patients to the study from our clinic, as did many doctors, but that was as far as it went...
  7. James

    Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort, 2018, Crawley et al

    Actometers that were specified for use in 2007 PACE trial protocol for patients at baseline but considered an unnecessary encumbrance on recovered participants at the end of the trial. Dutch FITNET did use ankle bracelet actometers but did not include data from them in the final published...
  8. James

    Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort, 2018, Crawley et al

    Total and moderate-to-vigorous physical activity and sedentary time at age 11 years were measured by accelerometry over a 7-day period. Surely not the same accelerometry that children found stigmatizing, so subjective reporting was the only possible recourse that researchers respecting children...
  9. James

    Results of the poll to inform the NIH/CDC’s definition of PEM in all their future ME/CFS research

    Reminded that the IOM committee also stated their definition was created for diagnostic rather than research cohort recruiting purposes which adds further credence that a stand alone PEM definition is urgently needed.
  10. James

    United Kingdom: The Royal Society of Medicine

    The medical community have respect from society but for those that know of him Wessely has no such luxury. https://www.thecanary.co/discovery/2017/10/18/dozens-leading-professionals-just-slammed-theresa-mays-controversial-new-mental-health-guru-letter/
  11. James

    Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C, 2018, Rosen et al

    University site gives a little background: https://liu.se/en/news-item/nytt-varningssystem-upptackt-i-kroppens-immunforsvar
  12. James

    Blog: Spoonseeker, "An Offer You Can’t Refuse"

    Mathew Hopkins as witch finder general offered similar choices, when carrying out investigations.
  13. James

    PIP claimants - email your experiences of the process to Laura Pidcock MP before Westminster debate next Wednesday

    DWP evidence would be wholly inadmissible in any other court https://www.disabilityrightsuk.org/news/2017/november/senior-judge-says-dwp-evidence-tribunals-so-poor-it-would-be-wholly-inadmissible Says all that needs be said about a rigged system that has been condemned in four UN reports...
  14. James

    Cerebral Blood Flow and Heart Rate Variability in Chronic Fatigue Syndrome: A Randomized Cross-Over Study (2018)

    CPET has shown the differences between groups is not apparent until the repeat session. HRV by finger sensor lacks the accuracy of chest straps when comparisons have been carried out using elite athletes, something that neither group meet criteria for and that brings up criteria used for...
  15. James

    Feedback from Stakeholder Engagement Workshop for the NICE guidelines on ME, Jan 2018

    Retaining treatments as the only ones that have any research evidence (SMILE Trial :( ) could be a dangerous place after Montgomery Vs Lanarkshire Health Board https://www.supremecourt.uk/cases/docs/uksc-2013-0136-judgment.pdf Informed Consent requires that any risk of harm that a reasonable...
  16. James

    Feedback from Stakeholder Engagement Workshop for the NICE guidelines on ME, Jan 2018

    That will render the severe and very severe as fortunate that they cannot access current treatment protocols from the clinics. How can abandoned by medical services and left to rot be the preferred option for any guideline.
  17. James

    Feedback from Stakeholder Engagement Workshop for the NICE guidelines on ME, Jan 2018

    “First, do no harm” from an ethical standpoint and acknowledging the exercise intolerance (SEID) that the IOM included in it's 2015 report. Removing criteria such as the Oxford criteria as the NIH Statement is unambiguous that the Oxford criteria are flawed and lack reliability, thereby...
  18. James

    Blog: Gelman, "The puzzle: Why do scientists typically respond to legitimate scientific criticism in an angry, defensive, closed, non-scientific way?"

    Paolo Macchiarini's position and defense of it by the Karolinska Institute would be a case in point where reputations and funding brought in by leading researchers outweigh the truth until a tipping point is reached that makes association with them toxic. Journals also have difficulty correcting...
  19. James

    CMRC - "Report of the fourth Annual Science Conference, 13/14th Sept 2017"

    Holgate has CMRC on track so merger with BACME will be all part of the big picture no doubt a shame as there were hopes of honest neutrality rather than providing apologies for funding the biopsychosocial model by the MRC.
  20. James

    Public Sessions Just Recriminalized Medical Cannabis

    Will cannabinoids with the THC removed be legal as they are in the UK, though I think large pharmaceutical companies would prefer that any alternative for their products were removed from the market soonest and have the political lobbying budget that generally prevails.
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