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Essentially the position they appear to be trying to take is that bad trial design is OK because patients are upset and call them names on Twitter. Nevermind that maybe patients are upset because of bad trial design and refusal to acknowledge the problems. Yes PACE was just a trial, but...

I'm getting the impression that several groups wanted to publish a B cell autoimmunity paper in case of a positive Rituximab trial.

What else does it say about PACE? (this article isn't yet available on sci-hub)

We haven't yet had a study that has examined this with good methodology and we need one. It is possible that the IOM criteria are worse than existing criteria (I'm assuming that all are flawed in one way or another and will be until more about the underlying biology is known).

A similar study using NorCAPITAL data was carried out for the Canadian criteria and also concluded that the diagnostic criteria make almost no difference: https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.12950 The diagnostic criteria for NorCAPITAL I'm not sure I'm ready to accept these...

The authors themselves say that

One can make the guess that SEID is being attacked because it's attached to the IOM report which states that the illness is not psychological in origin. If that paradigm were fully accepted, Wyller would find it harder to do the studies he has planned.

There is a link to the NorCAPITAL study here. https://clinicaltrials.gov/ct2/show/NCT01040429 I do not see any attempt to detect PEM. If they did not assess for PEM, they cannot possibly apply the SEID criteria since they require PEM to be present for a diagnosis.

But aren't they funded by patients in the UK?

Did Sharpe's twitter activity cause an increase in donations? He got a lot of responses to this from patients

Maybe that we cannot make any sense of their mind and body are one philosophy is because the value of it lies not in being an accurate framework for understanding illness but in advancing careers and financial interests. A political statement that justifies things like the existence of...

It's a quiet period in terms of research news but research interest and funding has been increasing so it must be due to chance.

What is/was Oxfam and why was it a threat to world peace? Edit: nevermind. It's a group of charities that want to reduce famine and poverty.

In my view the militant activist narrative is meant to discourage patients from speaking out. It is an attempt to manipulate our behaviour. They fear an uprising and that is exactly what is happening in some limited fashion. This uprising has still room to grow. The public sympathizes with...

I still believe in the hypometabolism hypothesis, even though this study suggests that (if it plays a role) it's not easily treatable. The study also suggests that a stimulant doesn't really work either.

The PACE trial used the Oxford criteria for diagnosis which suggests GET is generally ineffective even when broad criteria centering around unexplained significant chronic fatigue are used.

Do patients tend to get more herpes virus blisters compared to the normal population? I had that regularly as child. On the nose, around the mouth.

Someone seems to think this confirms CBT is better than medication. I have not read more than a few lines from this article and it's interesting that two opposed and incompatible interpretations are being made, much like in the PACE trial.

The CBT proponents seem rather nervous these days. They can see the end approaching. As Valentijn says in her comment, they have nobody but themselves to blame if the end of CBT for ME/CFS is rather unpleasant and embarassing.

@Lucibee is this something you're interested in?