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Exactly RCT means two different things. In the case of PACE, it means randomised comparison trial.

These sorts of articles are most often not written for the benefit of people with illnesses/disability, they're written so that able bodied people feel better about themselves...

Just because something is a "standardised" instrument doesn't mean it is reasonable or appropriate. Zero PROMs for example have been properly tested for acceptability, understandability, relevance/appropriateness to patients and so on. The fact is the construct validity of such measures have...

The problem is that vagal activity cannot be directly inferred from HRV or HRV-High Frequency band, as both sympathetic and parasympathetic activity have an effect on the HF component. Differences between patients and controls could simply be due to poor matching between patients and controls...

HRV is generally a poor choice for the measurement of vagal activity or parasympathetic/sympathetic balance, since it is affected by both... However the fact that TBARS did not change after exercise is notable. Previous studies found elevated TBARS after maximal exercise...

She also wrote an article about how the PACE study is crap.

Oh dear...

There is no "mild" ME, people should stop calling it that.

Really? I mean they're clearly a lobbying group, so...

It seems strange that they expect the biological research to be perfect while overlooking all the flaws in the psychological research, namely lack of specificity, sensitivity (when related to things like childhood trauma or allostatic load), lack of objective evidence of improvement etc. Seems...

Is this the full set of results? http://apps.chiragjpgroup.org/catch/

I've spent some time trying to uncover how the DTP results may be spurious - different travelling patterns of parents, perhaps more likely to have deaths recorded due to increased health system participation. But the results have appeared in multiple regions and even in a randomised study, so I...

My big toe circulation issues are not affected by temperature (not Raynauds specifically) and are not at all normal at my age (early 30s)! I've also never been a smoker. My issues aren't between the 3rd and 4th toe, so may be a totally different problem.

People generally leave rooms of successful motivational speakers somewhat poorer. ;)

We/you are assuming they have the same ideological basis as us/you. They don't believe that there is an underlying objective disease, they believe that subjective perception of pain/fatigue/whatever is the illness and that subjective reporting of improvements necessarily represents improvement...

Exactly. What you are recording is the output of an instrument, this cannot be assumed to be the same as the underlying phenomena. How a patient answers on a symptom questionnaire is not the same as the underlying experience of that symptom. Compared to voltmeters which have well-defined or...

That is an excellent point - the graph reflects cumulative incidence combined with lack of recovery. This can be modelled with Dismod etc too.

I've had a numb feeling at the bottom of my big toe for quite a while, in my case it is some kind of circulation issue as the toe on my other foot recovered after becoming very swollen after I stepped on a nail a few years ago.

Confusing cause and effect...

No. The problem isn't merely conflation of mental disorders with CFS. They're talking about poor quality easily-biased research and claiming it is somehow generalisable/conclusive evidence.