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There's funding for ageing cats, but not for humans with ME?

I think "quasiexperimental" means "We'll start with the results we want and make up the experiment to provide them." :rolleyes:

Researchers should put out a call for anyone who is able to trigger temporary remissions reliably, even if it's only for a few times. Get the patient in a lab, do extensive testing, trigger the remission, then redo the tests and see what's changed (and redo again when switched back out of...

I feel that an even stronger argument for ME being reversible is temporary remission. I had several, more frequently at the start, with the last one maybe in year 5 or so, with none in the last 14 or so years, alas. :( These were an abrupt switch from full ME to apparently fully healthy...

I have one (molar), gotten several years into my ME. I didn't have any problems healing quickly, or any other problems with it. My ME doesn't keep me inactive or horizontal though.

I didn't notice and difference in PEM between +30C and -40C. Swimming in my creek in winter would require considerably more effort. That water is hard! :D

I didn't notice any difference during PEM. For me it was just 'fatty meal without carnitine = worse symptoms. With carnitine = no extra symptom severity'. I didn't need 3000 mg either; I think I took half a level tsp or so.

At one point in my ME (maybe year 12?) I developed worse symptoms after eating fatty meals. That was treated by taking carnitine with the meal. After a year or two of supplementing carnitine, the problem went away.

My guess is that they'd find a similar correlation with most viral infections. I think that anything that influences the immune system(s) will have an effect on ME symptom severity.

My ME symptoms rose dramatically when I took extra tryptophan. Even quickly-digested carbs would make me feel worse 20 minutes later, which is expected as insulin boosts TRP transport into the brain, and is blocked by taking BCAAs. Furthermore, dietary niacin made me feel strongly suicidal. I...

Perhaps it's just the alkalinity of non-solvent cleaners. If baking soda or washing soda causes your dermatitis, then you'll have to avoid all alkaline cleaners. My hands are always really clean after kneading bread dough. Maybe try flour&water?

No mention of ME, which is too bad. It does add some details I hadn't been aware of before.

I did get a bladder infection once (year 18 or 19 of ME). Antibiotics did the trick. The infection didn't affect my ME symptoms (nor did the antibiotics). I can certainly believe that any sort of immune system activation event can possibly make some people's ME worse, but such things are not...

I'm not sure that the flaws in the study matter. I get the impression that even really well done studies that find something really significant ... simply won't be followed up on. :(

I agree that reliable before/during/after testing should provide a better chance of finding what changes. If I was doing the testing, I'd want EEG, CSF samples, and any other brain scanning that was available. If only blood and urine are available (cheap & convenient to sample), there might be...

For me, I think 'always, but the severity fluctuates a lot' fits best. Also, 'cognitive impairment' would be a better term, since ME causes cognitive symptoms that go beyond mere 'brainfog'.

I suppose it's a start. Better data might be obtained by monitoring eye movements and body movements and stance and other such involuntary factors. My guess is that even when reading (hold font, lighting, etc constant, and material similar), there will be a measurable difference in how long...

I agree with Jonathan: it's the lack of a clear physical measurement of ME that allows others to deny that it's a real disease. You can't actually be diagnosed with ME because there is no test for it; you can just get a doctor's opinion that you might have ME. Actually, even if there was a...

I notice a huge difference too. If I notice that I'm feeling cold, it's usually a day with high humidity. With a dry cold, I can spend hours outside at -30 or lower.

An additional problem is that ME seems to be a abnormal state that other processes in the body then try to maintain. Lots of us have had treatments that work great the first few times, and then they stop working and never work again. Something in our ME bodies responds to those treatments to...