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Thanks. The number of responses in the original Norwegian survey is really high. Could it be that ME/CFS is simply more prevalent in Norway than in other European countries?

I also would like to briefly share my thoughts on research priorities in ME/CFS. I know that many patients want biomedical research but having followed the literature for a while, my impression is that such type of research is usually a wild guess, with a low chance of returning anything...

Quote from the article: "If unpaid Minecraft mods can produce a 29-page mathematical analysis of Dream’s contested run, then scientists and editors can find the time to treat plausible fraud allegations with the seriousness they deserve."

Merged thread The Atlantic: Why Are Gamers So Much Better Than Scientists at Catching Fraud, 2021, by Stuart Ritchie A pair of recent cheating scandals—one in the “speedrunning” community of gamers, and one in medical research—call attention to an alarming contrast. Full text at...

I can't see the figure, unfortunately.

Thanks for doing these interviews.

Any thoughts on this study? @Simon M @Jonathan Edwards @Snow Leopard

From the Guardian article:

This study is an example of how easily patients' reporting of symptoms can be influenced by investigators. Priming is sort of the minimum influence you can do, much less than what usually happens in trials on behavioral interventions.

Abstract Background: Patient-reported outcome measures (PROMs) are influenced by psychosocial factors, but it is unknown whether we can influence PROM scores by modifying the mindset of the patient. Purpose: We assessed whether priming affects scores on PROMs. Methods: In all, 168 patients...

Strange. The author seems concerned with 'epidemic injustice' but then starts misrepresenting the views of patient representatives, saying that they should not focus solely on a biomedical model (without explaining clearly why this would be problematic). She seems to base her information on...

Looks like a good article. Most of what Stuart Ritchie writes is interesting and to the point. Does anyone know more about him or has anyone read his recent book?

Here's another example of a paper that writes: "Using subjective outcomes in an open-label study undermines its internal validity because it makes it impossible to determine how much of the reported effect is related to the investigated treatment and how much is related to various forms of...

Unfortunate article but at least the responses from COVID-rehabilitation doctors (Gordon McGregor, Sally Singh, Rachael Rogers, Paul Whitaker, and Rob Barker-Davies) don't sound so bad. Some seem aware of the problems with graded exercise and ME/CFS.

I've found multiple references that say when blinding is not possible, it is important to look at objective instead of subjective outcomes because are susceptible to bias. Here's a quote that suggests that lack of improvement on objective outcomes in unblinded trials may question the results of...

Oops, my mistake. I seem to have mistaken to data of sleep logs with baseline data. Apologies for the confusion, thanks for your analysis of the paper.

Thanks for the clarification. I was a bit confused by their data because they report the standard error instead of the standard deviation. The latter is 4-5 times larger than the former. EDIT: I made an error here. I seem to have mistaken to data of sleep logs with baseline data. Apologies for...

This study looked at how the control condition influenced effect sizes in trials on psychotherapy for depression. They found that waiting list control (WLC) and treatment as usual (TAU) were associated with much larger effect sizes. The authors report: "WLCs and TAU controls produced the...

Abstract Control conditions are the primary methodology used to reduce threats to internal validity in randomized controlled trials (RCTs). This meta-analysis examined the effects of control arm design and implementation on outcomes in RCTs examining psychological treatments for depression. A...

Anyone familiar with this 1998 document: ICH E9 STATISTICAL PRINCIPLES FOR CLINICAL TRIAL? I think ICH stands for The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). And it looks like their 1998 guideline was adopted by regulatory...