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No mention of ME, which is too bad. It does add some details I hadn't been aware of before.

I did get a bladder infection once (year 18 or 19 of ME). Antibiotics did the trick. The infection didn't affect my ME symptoms (nor did the antibiotics). I can certainly believe that any sort of immune system activation event can possibly make some people's ME worse, but such things are not...

I'm not sure that the flaws in the study matter. I get the impression that even really well done studies that find something really significant ... simply won't be followed up on. :(

I agree that reliable before/during/after testing should provide a better chance of finding what changes. If I was doing the testing, I'd want EEG, CSF samples, and any other brain scanning that was available. If only blood and urine are available (cheap & convenient to sample), there might be...

For me, I think 'always, but the severity fluctuates a lot' fits best. Also, 'cognitive impairment' would be a better term, since ME causes cognitive symptoms that go beyond mere 'brainfog'.

I suppose it's a start. Better data might be obtained by monitoring eye movements and body movements and stance and other such involuntary factors. My guess is that even when reading (hold font, lighting, etc constant, and material similar), there will be a measurable difference in how long...

I agree with Jonathan: it's the lack of a clear physical measurement of ME that allows others to deny that it's a real disease. You can't actually be diagnosed with ME because there is no test for it; you can just get a doctor's opinion that you might have ME. Actually, even if there was a...

I notice a huge difference too. If I notice that I'm feeling cold, it's usually a day with high humidity. With a dry cold, I can spend hours outside at -30 or lower.

An additional problem is that ME seems to be a abnormal state that other processes in the body then try to maintain. Lots of us have had treatments that work great the first few times, and then they stop working and never work again. Something in our ME bodies responds to those treatments to...

If that's not enough, they can call it 'quantum resonant biopsychosocial dysregulation' plus any other scientifically-sounding words that are popular with marketers. :rolleyes:

My ME problems with TRP seem to be in excess conversion to neurotoxic kynurenines in the brain. BCAAs can block, or at least delay and spread out the increase in symptom severity, so I'm pretty sure it's not a digestive system problem. Hopefully there won't be too many people with this...

I had to look up "central sensitisation". It looks like some scientific terms mushed together in a way that sounds impressive, but doesn't actually mean anything, or rather, that it can be used to explain nearly anything without providing any useful techniques for dealing with it. I don't...

I've encountered several treatments that worked well the first few times I tried them, then they stopped working and never worked again. That's just part of ME. I haven't come across any official hypotheses for this effect, but I assume that ME sets some factor in our cells that our bodies...

The title was so absurd that I had to check the thread. :)

"These dysregulated microglia are hyperreactive to signals from the peripheral immune system, producing an exaggerated and prolonged central cytokine response to an otherwise mild immune challenge. The primed microglia then become resistant to normal regulation, failing to revert to the...

If you define green light as a certain narrow part of the spectrum, then yes, but you'll get more in direct sunlight. If you want to define 'green light' for medical therapy as magnitude in that part of the spectrum and nearly no magnitude in the rest of the spectrum, then no, forest shade...

Melatonin can help me fall asleep, although it's not all that reliable. However, if I take it after 2AM, it leaves me feeling severely groggy the next day, worse than not sleeping at all. 5-HTP also worked, but I can't recall whether it had the same grogginess effect. Tryptophan might have...

I did suffer from neuropathic pain, but I treated that quite well with LDN, and after a year or so, I no longer had that pain. I still may develop it when my other ME symptoms are severe, but it passes on its own.

With any of the sleep meds, I'd worry about dependency.

I'm convinced that problems in the cerebral kynurenine system are a significant part of my ME, so this paper provides another possible explanation for how.