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Yep. We are perfectly capable of reconditioning ourselves — if only our bodies would allow that.

I think they are seeing things through the lens of exercise science, because most of them are exericse scientists. The focus on physical exercise and rehab is party, I think, because many still think PEM is just about exercise intolerance — this is something I tried to convey in my response. So...

Ah ok. Yes, these are not blanket statements — they are refering to the individual patient, but perhaps that's not clear. "if there is no evidence of deconditioning in a patient" night have been better.

The crux is what is driving these abnormalities. You could get similar results, for example in CPET, from very different mechanisms, which is sort of what Charlton et al are arguing. I don't intend to argue that deconditioning isn't present in some patients, only that we should challenge the...

I have just subitted the following rapid response. Not sure how often this journal publishes RRs, and this might be too off-topic for a sports medicine journal, so I'm posting here. It was helpful to get my thoughts in order, but now I need a break. -- Post-exertional malaise cannot be reduced...

That is more in line with most estimates, but the range is huge.

For me, the issue is the simplisitic cause–effect language that is used to describe exertion and PEM. It's just not that simple in reality. There seems to be an element of randomness and it's very easy for patients to fall into the trap of over-attributing PEM and crashes to exertion/activity...

Do the findings of the recent Ryback et al. paper refute these results?

Thread here about a FOI request by @Lucibee showing pitiful numbers of NHS staff taking the ME/CFS Delivery Plan e-learning courses. https://skyview.social/?url=https%3A%2F%2Fbsky.app%2Fprofile%2Flucibee.bsky.social%2Fpost%2F3megstha5j22m&viewtype=tree Twitter link here:

Highlights • Semaglutide alleviates OA in a weight loss-independent manner • Semaglutide shifts chondrocyte metabolism from glycolysis to oxidative phosphorylation • Semaglutide exerts its chondroprotective effect via the “GLP-1R-AMPK-PFKFB3” axis • Semaglutide could serve as an effective drug...

I don't have phobias but I do have OCD and I was in my 30s before I realised that OCD was a form and manifestation of anxiety. It had never really clicked before. It certainly makes sense to me that phobias are included under the banner of anxiety. Like OCD, phobias are essentially underpinned...

What a bizzare trial design, which has made it harder to test whether the intervention has benefit.

What comprises the 'blurb' here? And what's wrong with it? (I am interested in the lack of fatigue research, given it is a core feature of so many different diseases and illnesses.)

Recording here:

This could be quite helpful, though I no longer use Word and wish we could have a Google Docs version of stuff like this. EDIT: I opened it in Google Docs and it seems the formatting is preserved.

Loren Kell seems to be Douglas's daughter. She's a post-doc at Oxford in the area of immunosenescence and ageing so would be good to get her involved in more ME/CFS research.

Postural orthostatic tachycardia syndrome (POTS) is a complex disorder mainly of orthostatic intolerance, often accompanied by a spectrum of symptoms related to autonomic nervous system dysfunction. Although the diagnostic criteria require an orthostatic challenge test, the associated symptom...

I know we've had this conversation before, but who is bdding for these contracts? Is it hospitals?

Yeah, but I'm not sure if it's the peppers or just the capsaicin. I do think the pickling is a part of it. I have never really looked into FODMAP in any depth, or followed a FODMAP diet. I suppose I could experiment on myself....

I have had IBS since my university days. Yes, it's a vague diagnosis, but until we know more it seems to fit my symptoms. Luckily it's mostly mild but I have to be careful with what I eat. Caffeine was a big trigger but I've been on decaf tea and coffee for a few years now. Unfortunately, some...