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I have just subitted the following rapid response. Not sure how often this journal publishes RRs, and this might be too off-topic for a sports medicine journal, so I'm posting here. It was helpful to get my thoughts in order, but now I need a break. -- Post-exertional malaise cannot be reduced...

That is more in line with most estimates, but the range is huge.

For me, the issue is the simplisitic cause–effect language that is used to describe exertion and PEM. It's just not that simple in reality. There seems to be an element of randomness and it's very easy for patients to fall into the trap of over-attributing PEM and crashes to exertion/activity...

Do the findings of the recent Ryback et al. paper refute these results?

Thread here about a FOI request by @Lucibee showing pitiful numbers of NHS staff taking the ME/CFS Delivery Plan e-learning courses. https://skyview.social/?url=https%3A%2F%2Fbsky.app%2Fprofile%2Flucibee.bsky.social%2Fpost%2F3megstha5j22m&viewtype=tree Twitter link here:

Highlights • Semaglutide alleviates OA in a weight loss-independent manner • Semaglutide shifts chondrocyte metabolism from glycolysis to oxidative phosphorylation • Semaglutide exerts its chondroprotective effect via the “GLP-1R-AMPK-PFKFB3” axis • Semaglutide could serve as an effective drug...

I don't have phobias but I do have OCD and I was in my 30s before I realised that OCD was a form and manifestation of anxiety. It had never really clicked before. It certainly makes sense to me that phobias are included under the banner of anxiety. Like OCD, phobias are essentially underpinned...

What a bizzare trial design, which has made it harder to test whether the intervention has benefit.

What comprises the 'blurb' here? And what's wrong with it? (I am interested in the lack of fatigue research, given it is a core feature of so many different diseases and illnesses.)

Recording here:

This could be quite helpful, though I no longer use Word and wish we could have a Google Docs version of stuff like this. EDIT: I opened it in Google Docs and it seems the formatting is preserved.

Loren Kell seems to be Douglas's daughter. She's a post-doc at Oxford in the area of immunosenescence and ageing so would be good to get her involved in more ME/CFS research.

Postural orthostatic tachycardia syndrome (POTS) is a complex disorder mainly of orthostatic intolerance, often accompanied by a spectrum of symptoms related to autonomic nervous system dysfunction. Although the diagnostic criteria require an orthostatic challenge test, the associated symptom...

I know we've had this conversation before, but who is bdding for these contracts? Is it hospitals?

Yeah, but I'm not sure if it's the peppers or just the capsaicin. I do think the pickling is a part of it. I have never really looked into FODMAP in any depth, or followed a FODMAP diet. I suppose I could experiment on myself....

I have had IBS since my university days. Yes, it's a vague diagnosis, but until we know more it seems to fit my symptoms. Luckily it's mostly mild but I have to be careful with what I eat. Caffeine was a big trigger but I've been on decaf tea and coffee for a few years now. Unfortunately, some...

If it isn't our old friend Jake Hollis again, with more nonsense speculation!

Essentially, yes: his theory is that SNS activation and 'stress' leads to dysfunctional smooth muscle contractions that 'pump' lymph around the body in lymphatic vessels, which then leads to a build up of 'toxins'. The question then becomes: why wouldn't this cause a build up of fluid in...

This is exactly how I describe it. It takes me till lunch most days to 'come round', and it's usually evening before I feel at my best.

Yes, I get this, although it's not always a consistent pattern. I can wake after say 7 hours and feel more awake, and then after 9 or 10, which I need, I more frequently get the drugged/concussed feeling.