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I would say this is still a little inaccurate. DecodeME didn't find differences in genes, they found differences in genetic variants. As far as I can tell, the mapping of these variants to immune or nervous system genes is still very speculative. The other two main findings are the MAGMA...

They saw basically the same pattern in the idiopathic chronic fatigue group, so I think probably not just chance: Maybe just that more viral infections happen in the winter.

From paper:

Sex Differences in Long COVID Prevalence Over One year After the Acute Phase, and Related Risk Factors. The GINA-COVID Cohort Study Background This 1-year cohort study aimed to track long COVID prevalence, identify associated risk factors, and assess its association with hospitalization...

The efficacy of exercise in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis Zhao, Liping; Gou, Bo; Zhang, Meng Objective To evaluate the efficacy of exercise training for patients with myalgic encephalomyelitis/chronic fatigue syndrome...

I don't see anything that suggests 23andMe would report a thymine when there is no thymine. And contrary to what DonnellanP just said: That page looks like evidence that they do expect individuals to go through their DNA and look at their alleles.

Based on zero evidence presented by you, despite several requests to understand why you are saying this.

I have continued searching for terms that are highly correlated to search interest for "chronic fatigue syndrome" at the metro level, using the program I used before (with some alterations for finding better related terms to test, such as having an AI suggest related terms). I actually...

Just adding a link to a thread for the study: Sex effects on gene expression across the human cerebral cortex at cell type resolution 2026 DeCasien et al

Here are links to some of them: General discussions Migraines caused by ME - How to discuss with Neuro? Migraine treatments Are there symptoms you had in the early stages of ME that you no longer get? - Some =477&o=date']mentions of migraine Why has 'persistent enteroviral infection' been...

Genetic correlation A recent preprint found a genetic correlation of rg=0.45 between ME/CFS (DecodeME) and a USA migraine cohort. This figure is similar to the genetic correlation value I found when testing correlation of DecodeME with other migraine cohorts (UK BioBank and FinnGen). Insights...

I thought it'd be good to have a public thread for general discussion about how ME/CFS and migraines may be related. We have a members only thread for sharing experiences as well. Mainly, I want to link relevant discussions happening on various threads, so they don't eventually get buried.

The following study is actually about incidence rate, and brings the second peak in line with the figures for the second ME/CFS incidence peak. The first peak is a bit later than in ME/CFS, though. Another study for incidence rate peaks. It's a small (n=75) study, only on those with Von...

Oh, actually, this is comparing incidence peaks in ME/CFS to prevalence peaks in migraine. I think prevalence would be expected to peak later, though I'm not sure how much later. So maybe the ages of the migraine peaks are closer to ME/CFS than it seems from this.

The first MAGMA plot above is for 54 specific tissues. For the more general tissue grouping, there were two significant tissues showing enrichment of GWAS genes, both in the full cohort, and in the men-only cohort: brain and uterus. Here is the plot for men: This is interesting, because males...

They did a lot of comparing their findings to a previous migraine GWAS: New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis (2021, Communications Biology) I took a look at that paper, and interestingly, in the MAGMA analysis in that study...

Some other studies to potentially look at. I just quickly grabbed quotes about bimodal distributions, and haven't read the papers: Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China (2023, J Headache...

Ages for peaks from ME/CFS papers, to compare to this study: StudyConditionFirst peak (SD)Second peak (SD) Bakken 2024ME/CFS10-1930-39 McGrath 2026ME/CFS16 (4.3)36.6 (10.5) Victor 2010Migraine (Women)25 (8.6)50 (15.8) Victor 2010Migraine (Men)18.7 (7.4)47.6 (16.8) The peaks seem to...

Speculating that hormonal changes might cause second peak in men. Previous studies had not seen this bimodal effect. They speculate that it is because other studies used 5 year age groups instead of 1 year, and because they used populations that didn't span as large of a range in ages as this...

This study was found by Murph when discussing whether migraine and ME/CFS may be related: I posted so we could examine whether the bimodal distribution looks like it might be showing the same thing as in two ME/CFS papers: Two age peaks in the incidence of chronic fatigue syndrome/myalgic...