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Could you clarify why this is a problem?

Pediatric post-acute sequelae of SARS-CoV-2 infection in Taiwan: Insights from the DISCOVER cohort Abstract The post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, represent a multifaceted challenge in pediatric populations, characterized by symptoms persisting beyond the acute...

Two-timepoint multidomain follow-up of post-COVID condition and ME/CFS: overlapping autonomic, small-fiber, and cognitive changes Background Post-COVID condition (PCC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) show marked clinical overlap, suggesting a shared...

A couple musings about how MAGMA might potentially be able to provide more interesting results: 1. Maybe it would be interesting to correlate MAGMA gene scores to protein levels instead of mRNA expression. It might be a better metric for how important a gene is to a cell, as the protein is the...

Just linking to relevant discussion about how MAGMA on DecodeME sumstats is sensitive to the window size around the genes: https://s4me.info/threads/biological-insights-from-genome-wide-association-studies-and-whole-genome-sequencing-of-me-cfs-2026-maccallini-et-al.50225/post-699621

The differences of PSRT to MBSR and usual care seem fairly consistent across outcomes. In the table above for RDQ, the drop in score from week 0 to 4 seems fairly large compared to the other groups. It looks like the difference between PSRT and the other groups becomes smaller with time. In the...

Table 3 shows the between group differences at each time point for the first three outcomes. Here are the results for just the primary outcome, RDQ/functional disability, in each group at each timepoint. Time point (wk)PSRT mean ± SDMBSR mean ± SDUsual care mean ± SDComparison (PSRT and...

This study was testing psychophysiologic symptom relief therapy (PSRT) to see if it is superior to mindfulness-based stress reduction (MBSR) or usual care in reducing disability and symptoms related to chronic back pain that lacked a clear organic etiology. There was randomization into the...

From the same investigator, and a similar intervention, of an upcoming trial of a mind-body intervention for long COVID. I thought it might be worth looking at the findings of the intervention for pain.

Psychophysiologic symptom relief therapy for chronic back pain: a pilot randomized controlled trial Introduction: Chronic back pain is the leading cause of disability in the United States. Based on the hypothesis that nonspecific back pain may be rooted in a psychophysiologic etiology, we...

I found the same thing in my initial attempts to just do MAGMA on GTEx tissues. I saw that the brain tissues were much less significant than in DecodeME and @tralfamadorian97's same analyses, and I realized the biggest difference was because I used 35,10 and tralfamadorian used a 0,0 window...

I think the registration is just lacking in detail. Here is a previous study on pain where they also did a three arm trial focused on a mind-body intervention. The control group was "mindfulness-based stress reduction". Psychophysiologic symptom relief therapy for chronic back pain: a pilot...

The trial website says recruiting, but the principal investigator posted on social media on June 5 that enrollment is closed, so I've edited the title.

Here is the preprint for the pilot study from this researcher, which describes the intervention they use in more detail. I assume the present study will use a similar intervention. Psychophysiologic symptom relief therapy (PSRT) for post-acute sequelae of COVID-19: a non-randomized...

I've made a thread for that trial registration: Mind Body Intervention for Long COVID-19 [Massachusetts, USA]

Official Title Mind Body Intervention for Long COVID-19 Brief Summary The goal of this study is to determine if a mind-body intervention can help people suffering from symptoms associated with Long COVID.The study is a randomized trial examining the effectiveness of a mind body intervention in...

I think a lot of people here did believe they might be in such a subset for a significant chunk of their early illness. And for a lot of people, there were months or years of it not helping. And then there was also getting a more realistic outlook on what the scientific evidence shows compared...

If the trial comes out and there are issues in the interpretation, should members just not mention them? Criticisms are made about studies of all subject matter here. If Donnino describes the trial as a success, does that mean that the results are "positive"? Or is it if you decide the results...

He would likely respond similarly to a previous reply about this:

Raman Spectroscopy Combined with Machine Learning Reveals Myalgic Encephalomyelitis–Associated Biomolecular Signatures at Rest and After Standardized Stress Abstract Myalgic encephalomyelitis (ME) is characterized by profound fatigue, post-exertional malaise (PEM), and cognitive dysfunction...