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Apologies - that looked great on my laptop, but what a mess. Now as screenprints, repeated below: I agree the severity difference is more impressive, and that having more severe illness tends to go with more symptoms too (though I think more severe symptoms can be at least as bad as more...

Thanks for this helpful reply. I've been digging more into the numbers, and I'm not sure that the High symptom burden cluster is so much more severe than the low one. This is the data from the supplementary table showing illness severity by symptom clusters. Please should if I have made any...

Only if it is demonstrated to be true. A core purpose of research is to test hypotheses, not to prove them (as the goal of research) or to assert them. Proposal of hypotheses is good - if there is follow up to test them, which happens quite a lot in other fields.

An interesting study. I don't have the energy to read the paper, but I'd i'd like to know more about the definition of symptom burden/symptoms severity. Was this simply symptom count? I'm pretty sure that they didn't ask participants about the severity of individual symptoms. And I think...

Thanks for those explanations. It's striking how ME/CFS stands out, along with schizophrenia, with one tissue type dominating so much. I'm trying to understand how this creates a vulnerability, an increased risk of ME/CFS , which is what GWAS measure. That's easier to understand with immune...

I appreciate all the thoughts, analysis and research that is going into your work. I'm also losing the thread a bit (that's my brain, not your explanations.). Is this gene expression work highlighting tissue and cell types in mice and human where DecodeME (etc) highlighted genes are...

I imagine the simplest way to get this dosage data would be to compare the proportions of these with the various X-chromosome make-up spelled out above in the DecodeME cohort versus the general population. Although I don't know if DecodeME collected such data.

Thanks for a really interesting analysis. This is my concern. I think the prevalence in the MVP sample using this coding is about 1.5%, vastly higher than any reliable estimates we have for. ME/CFS. The hospital episode statistic study from Samms and Ponting came up with 0.6%, but that's for a...

(So they did X chromosome analysis? ) I thought the point was that one of the X chromosomes in females issilenced, but the silencing is incomplete so that there is a double dose (or more than a single dose) of some genes?

Thanks, I appreciate the feedback because that's whet I try to do - make this pretty technical stuff understandable to those who don't have the technical knowledge but have the illness and want to understand the research. And thanks to all those who have left similar feedback (or just kind words).

I don't read much poetry, but I love what you write. I love how you can distill so much into so few words – and above all, how you capture the emotions and experience of living with this illness. And how you describe your own. Thanks so much.

Yes, according to Chris. Although it's qualified by this kind of long-Read sequencing that also picks up epigenetic signals. It is, astonishing, though and something to celebrate. Sorry for the ambiguity – I was saying that the samples are good to go. Which obviously saves a huge amount of...

It wouldn't, because of the samples. And thanks re video - credit to @Adam pwme for the video creation. My thanks for his work and his patience (animations from Oxford nanopore, words and any errors by me), Thanks. Does this work? This is an extraordinary moment for ME/CFS. It used to get by on...

DNA sequencing study to help pinpoint biology of ME gets £4.7m The science of Sequence ME and Long Covid The UK government has awarded nearly £5 million to fund full sequencing of the DNA of 6,000 people with ME using the best available technology. This will help scientists home in on what is...

The award is from the Office for Life Science, and I Think Part of Its Remit Is Promoting Innovation in Healthcare. I understand from Chris Ponting) that this will be the largest full genome sequencing a single disease so far. Suddenly, ME/CFS is moving from the back of the queue to being at...

That is seriously impressive. Congratulations. That's interesting. Charities don't usually like restricting donations in this way but for such an important study like this, it make sense.

My understanding is that the responder was not shown any options - they just state the illness, and the nurse chooses the option. Maybe chronic fatigue was incorrectly coded as CFS. CF has various estimates, but 4% isn't far off. Also note that the average age of the cohort at recruitment, the...

Thank you, @dave30th, this is a great video.

Me too. It was great to work closely with her and Charlie Hillier @chillier on the study – they are an impressive team.

Thanks for all the great work on this, @forestglip I'm finding it pretty hard to interpret the findings for several reasons: - Many previous studies didn't find a bimodal pattern, and with out digging in to them, it's hard to be sure why that was. - there seem to be differences by sex - and also...