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Interesting re age profile. When I queried the use of amitriptyline in children ( can be as young as 10 to my knowledge) and asked for evidence re impact on developing brain and efficacy with paediatrician there was an awkward pause. I suspect a lot of the drug interventions for those...

Mouse model but intriguing. My daughter has lymph issues often ( it doesn't t really go away, just seems to ramp up and down) Could this be one of the causes of pain in this area? https://www.the-scientist.com/news-opinion/brains-fluid-drains-via-lymphatic-vessels-at-the-base-of-the-skull-66193

I expect EC is an excellent teacher. It's s a case of " the king is dead, long live the king"

It's preparing for more privatised spin offs from NHS in lieu of direct provision. How many private companies currently provide CBT therapy, who has a financial stake in them, and where do they operate? The fact that you don't need robust evidence has done nothing to halt the IAPT roll...

People would have died. That's the main difference that accounts for where we are. Not enough people have died with ME being on death certificate.

This

Thank you

Sociopath

Another questionnaire...

Illustrates perhaps why there is so little follow up . A follow up study of participants may be illuminating.

I think the most forgotten " hole in the energy bucket" to borrow the Myhill phrase is the emotional one. It is so difficult to predict or plan for this and it can have huge effects. My severely ill aunt's s labrador is 13 and literally on her last legs. Everyone knows that the inevitable...

Saw this on Twitter Designed for menstrual cramp - brilliant for pain relief for so many conditions Hope it is mass manufactured soon https://news.engineering.utoronto.ca/this-ultra-thin-hot-water-bottle-could-help-ease-menstrual-pain/

It's the concept of fatiguability that seems so hard for people to grasp Fatigue is not the most onorous nor annoying symptom and yet it is the most quoted / first symptom on a list. Why?

Brilliant again. Well done and thank you. Xx

Many different chip versions affect which Gene's are picked up. To be robust chip version may need defined?

Sadly this is potentially evidence base for NICE. Similarly the n=1 account of intensive therapy for a teenage boy with severe ME which reads like torture. There is very little biomedical research for paediatric/ adolescents. A muscle study which Tymes Trust were involved with ( Dundee uni) ...

And here we have Gigi facing the same fate.

Referred pain diagram may help. Also, given the recent metabolonic research , could maybe be due to.purines?

Perhaps one for Gigi would work - very simple, concise and no ambiguity.

The problem is that the methodology goes wider and affects many more conditions and careers. When it comes to eminence, the pace of change in UK is slower than a snail's .