autoantibodies

Abstract Purpose Previous studies demonstrated M2 muscarinic acetylcholine receptor-activating autoantibodies (M2R-AAb) were present in some patients with postural tachycardia syndrome (POTS). This study examines how these autoantibodies might contribute to the pathophysiology of POTS, and...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...

vvv Source: Medical Immunology Vol 23, #4, pp 975-980 Date: July/August 2021 URL: https://www.mimmun.ru/mimmun/article/view/2439 https://www.mimmun.ru/mimmun/article/view/2439/1456 Early diagnostics of autoinflammatory disorders associated with post-viral chronic fatigue...

Abstract Background Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of the AT1 receptor and...

https://pubmed.ncbi.nlm.nih.gov/34484936/ Abstract Objective: Postural tachycardia syndrome (POTS), the most common form of dysautonomia, may be associated with autoimmunity in some cases. Autoantibodies against the ganglionic acetylcholine receptor (gAChR) have been reported in a minority of...

Abstract Functional autoantibodies directed to the M2 muscarinic acetylcholine receptor (M2R) could affect the heart rate directly by altering cardiac M2R activity and/or indirectly by changing vagal-mediated cardiac M2R activity. We measured M2R autoantibody activity in sera from 10 subjects...

Full title: Neutralization of Autoantibodies Targeting G-Protein Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms after COVID-19 Infection Abstract Clinical features of Corona Virus Disease 2019 (COVID-19) are caused by the severe acute respiratory syndrome coronavirus-2...

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Scheibenbogen et al Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an...

Abstract Context Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe chronic illness which reduces the quality of life. A potential role of neuroendocrine autoimmune dysfunction has been hypothesized. Objective To investigate the occurrence of anti-pituitary (APA) and...

Autoantibody helps with Long Covid The German article https://www.fau.de/2021/07/news/medikament-gegen-autoantikoerper-hilft-bei-long-covid/ The paper is most interesting because of microcirculation, plus the use of BC 007, originally a heart related drug, as a treatment...

Nature - molecular psychiatry Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? - Bornstein et al Abstract As millions of patients have been infected by SARS-CoV-2 virus a vast number of individuals complain about continuing...

I personally believe that ME/CFS is antibody driven and I therefore think this breakthrough technology could tell us alot about at least a subset of patients. Here you can identify antibodies to extracelluar proteins (non tissue degenerating) which relates to us as patients since there is no...

Touches on ME/CFS

Abstract Impairment of health after overcoming the acute phase of COVID-19 is being observed more and more frequently. Here different symptoms of neurological and/or cardiological origin have been reported. With symptoms, which are very similar to the ones reported but are not caused by...

RETRACTED - link to post Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls (note: Dr Klimas is a co-author, and ME/cfs was used as a control but it does not appear to highlight results at first glance)...

The antinuclear antibody dense fine speckled pattern and possible clinical associations: An indication of a proinflammatory microenvironment (2020) Lundgren et al Abstract Background: Indirect immunofluorescence (IIF) is the most prevalent screening antinuclear antibody test for systemic...

RETRACTED - link to post Full Title: Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls Gulf War Illness the main focus of the study but they had a control group of 50 people with ME/CFS My bolding...

https://www.mdpi.com/2077-0383/9/8/2443

Full title Autoantibodies to Beta-Adrenergic and Muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – a validation study in plasma and cerebrospinal fluid from two Swedish cohorts Journal Brain, Behavior, & Immunity - Health Authors Annie Bynke, Per Julin, Carl-Gerhard...

Paywall, https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12751 Sci hub, https://sci-hub.tw/10.1111/jon.12751