b cells

Prolactin modulates the naive B cell repertoire Abstract Prolactin is a peptide hormone produced by the anterior pituitary gland that is critical in lactation. Prolactin can also be produced by lymphocytes, and both B and T cells express prolactin receptors. These findings have suggested that...

EBV Reprograms B Cells in an Autoimmune-Like Fashion in Patients with COVID-19 Epstein-Barr virus (EBV) reprograms B cells in autoimmune disease. Reprogrammed EBV+ B cells activate nearby B and CD4+ T cells, via upregulated antigen presentation and costimulatory machinery, to drive autoimmune...

Co-option of retrotransposons promotes antibody diversification Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of VH(D)JH genes in germinal center B cells for antibody diversification and affinity maturation. How AID specifically targets VH(D)JH remains...

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain INTRODUCTION Synaptic elimination is a fundamental process that can engage microglia and the classical complement cascade, yet the mechanisms that specify which synapses are targeted by complement component 1q...

Abstract The COVID-19 pandemic has infected more than 778 million people worldwide. Roughly 7% of these patients progress to Long COVID (LC), suffering from persistent symptoms and cognitive impairment well past the acute stage. As the mechanisms of LC remain elusive, we utilized single-cell...

Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease driven by uncensored B and T cell autoreactivity. Understanding this pathogenic process has been...

Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell–Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome BACKGROUND Long COVID (LC) is characterized by symptoms persisting at least 3 months after...

B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism B cells are an essential component of humoral immunity, and B cell depletion therapies have clinically succeeded in eliminating cancerous B cells and treating autoimmune diseases. Here, we report an...

Persistent Gut-Immune Axis dysregulation in long-term Post-COVID Syndrome: Insights from a prospective, observational, cross-sectional case-control study Post-COVID syndrome (PCS) is a complex condition that can emerge after recovery from SARS-CoV-2 infection, even in young, healthy...

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...

Baseline Dysregulation in B, T, and NK Cells in COVID-19 Predicts Increased Late Mortality but Not Long-COVID Symptoms: Results from a Single-Center Observational Study The SARS-CoV-2 pandemic presents a broad clinical spectrum from asymptomatic cases to severe respiratory failure with high...

Do self-perpetuating B lymphocytes drive human autoimmune disease? Jonathan C W Edwards, Geraldine Cambridge, Vikki M Abrahams Published: 1999 [Line breaks added] Abstract Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are...

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women Salker, Madhuri S. ; Abd Aziz, Nor Haslinda ; Prodan, Natalia Carman ; Yang, Zhiqi ; Lankapalli, Aditya Kumar ; Lazar, Katrin ; Shafiee, Mohamad Nasir ; Kocak, Ersoy ; Ganesan, Harivignesh...

ME Group Australia YouTube Channel posted a talk with @DMissa "Understanding ME: Investigating cellular and body-wide features of ME" Dr Daniel Missailidis, PhD, discusses his work over the last 10 years in a very easy to understand way. The biggest finding to date from this team has been...

Zheyi Wang, Zetai Bai & Yize Sun Abstract Background Accumulating evidence has hinted at a correlation between immune cells and post-viral fatigue syndrome (PVFS). However, it is still ambiguous whether these associations indicate a causal connection. Objective To elucidate the potential...

Immune disturbances in individuals with post-COVID syndrome are not characterized by enhanced SARS-CoV-2-specific immunity Ober, Veronica; Völk, Felix; Sbierski-Kind, Julia; Gruener, Eva; Stirner, Renate; Reiling, Gabriele; Feldmann, Svenja; Ibarra, Gerardo; Seybold, Ulrich; Stubbe, Hans...

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis Sai Zhang; Fereshteh Jahanbani; Varuna Chander; Martin Kjellberg; Menghui Liu; Katherine Glass; David Iu; Faraz Ahmed; Han Li; Rajan Douglas Maynard; Tristan Chou...

B Cell Dynamics and Transitional B Cells in Long COVID Zoia R. Korobova, Natalia A. Arsentieva, Natalia E. Liubimova, Oleg K. Batsunov, Anastasia A. Butenko, Albina E. Kokoeva, Natalia G. Kucherenko, Victor A. Kashchenko, Ekaterina V. Boeva, Anna O. Norka, Anastasia A. Knizhnikova, Vadim V...

I’ve been reading/listening to lots about the immune system, particularly B and T cells. And thought it may be worth sharing some links to info I’ve found useful. If others have useful resources please chip in! There’s a lot of sources here and duplication, I found reading/listening to...