By Open Medicine Foundation
full article here:
https://www.sanluisobispo.com/news/state/california/article229756099.html
[have looked at the link but can't find the published paper?]
eta: link now works
this one takes you to where it's listed...
Background
Neutrophil-to-lymphocyte ratio (NLR) has proven its prognostic value in cardiovascular diseases, infections, inflammatory diseases and in several types of cancers. However, no cut-off has been proposed on the basis of reference values coming from healthy population.
Methods
Routine...
I haven't looked at this, but it sounds interesting and relevant.
It is accepted by the CBT-GET promoters that there are biological changes in patients with ME. A key part of their argument has always been that psychotherapy can bring about or reverse biological changes.
Here is a study that...
Paywalled at https://link.springer.com/article/10.1007/s12035-019-1549-7
alt https://sci-hub.se/https://link.springer.com/article/10.1007/s12035-019-1549-7
Impact of Polypharmacy on Candidate Biomarker miRNomes for the Diagnosis of Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Striking Back on Treatments
Eloy Almenar-Pérez 1, Teresa Sánchez-Fito 1, Tamara Ovejero 2, Lubov Nathanson 3,4 and Elisa Oltra 2,5,*
1
Escuela de...
Scheibenbogen et al (2016), The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE , Journal of Translational Medicine, https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1263-z#Sec4
pdf: The European ME/CFS Biomarker Landscape...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1161-4
Background
Investigations of activin family proteins as serum biomarkers for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). CFS/ME is a disease with complex, wide-ranging symptoms, featuring...
All of authors are from University of Bristol and include Crawley's mate, George Davey Smith. ME gets mentioned a number of times.
Open access at https://www.nature.com/articles/s41598-019-39359-z
Starting to build a narrative that our fatigue isn't anything out of the ordinary?
An objective biomarker - gene expression patterns - for pain? Can this be true?
https://www.nature.com/articles/s41380-018-0345-5 (A.B Niculescu et al.) Full text.
The cohorts and the scientists are psychiatric patients/psychiatrists but otherwise the study seems to lean more biomedical - not...
Might increased serum NfL also be a potential biomarker for ME/CFS since it is for Alzheimer’s and other neurological disorders?
https://www.nature.com/articles/s41591-018-0304-3
www.bloodjournal.org/content/132/Suppl_1/4874
At the moment, the full article is not yet available.
Edit: We have 3 threads on related or the same research by the same team:
Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome, Davis et al (2018)
Altered Erythrocyte...
2018
biomarker
davis
erythrocyte deformability
erythrocyte sedimentation rate
me/cfs
oxidative stress
paper
red blood cell deformability
red blood cells
simpson
Source: Frontiers in Neurology
Preprint
Date: November 5, 2018
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2018.00992/abstract
Hand grip strength as a clinical biomarker for ME/CFS and disease
severity
----------------------------------------------------------
Luis C. Nacul(*)...
I've never had a flu jab my entire life (I'm 56), and don't feel that I've ever gotten the flu. Of course it's difficult to know for sure with M.E because I feel viral-like 80% of the time.
Perhaps I get a milder form when exposed but not sure.
Researchers at Stanford have discovered a way...
Moderator note:
Link to @forestglip's excellent summary of what is known, as of August 2026, about the prolactin response to a buspirone challenge in ME/CFS here
See also a Google document where some members are compiling findings and ideas related to prolactin response here.
********
I...
Scientific American article on the search for an Alzheimer's biomarker, and how both the FDA and Bill Gates have made finding an inexpensive blood test for Alzheimer's a priority.
We Need New Biomarkers for Alzheimer's Disease
They're essential to coming up with better treatments, and a new...
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