A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk
Verdier, Hippolyte; Thomas, Patrick; Batista, Joana; Kempster, Carly; McKinney, Harriet; Gleadall, Nicholas; Danesh, John; Mumford, Andrew; Heemskerk, Johan W. M.; Ouwehand, Willem H...
Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis
Jue Wang; Shiva Keshava; Kaushik Das; Richard Kolesnick; Xian-Cheng Jiang; Usha R. Pendurthi; L. Vijaya Mohan Rao
BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue...
Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolism
Wen Dai; Mark Castleberry; Ze Zheng
Fibrinolysis is an enzymatic process that breaks down fibrin clots, while dyslipidemia refers to abnormal levels of lipids and lipoproteins in the blood. Both...
Cerebrospinal Fluid Proteomic Profiles in Patients with Postherpetic Neuralgia
Kai Chen; Meng Wang; Dongju Long; Dingquan Zou; Xin Li; Ruixuan Wang; Yaping Wang; Lin Yang
The intrinsic mechanism of postherpetic neuralgia (PHN) remains unclear. Herein, we aimed to seek the hub proteins in the...
Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants
Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...
Longitudinal viscosity of blood plasma for rapid COVID-19 prognostics
Jennifer Illibauer; Tamara Clodi-Seitz; Alexander Zoufaly; Judith H Aberle; Wolfgang J Weninger; Manuela Foedinger; Kareem Elsayad
Blood Plasma Viscosity (PV) is an established biomarker for numerous diseases. While PV...
Emerging Links Between COVID-19 and Cardiovascular & Cerebrovascular Thromboembolic Events: A Systematic Review
Abstract
COVID-19, caused by the SARS-CoV-2 virus, initially identified as a respiratory illness, has increasingly been linked to a broader range of organ complications. This...
Hemostatic abnormalities in patients with Ehlers–Danlos syndrome
A. Artoni; A. Bassotti; M. Abbattista; B. Marinelli; A. Lecchi; F. Gianniello; M. Clerici; P. Bucciarelli; S. La Marca; F. Peyvandi; I. Martinelli
Background: Ehlers–Danlos syndrome (EDS) includes a heterogeneous group of...
Characterization of bleeding symptoms in Ehlers–Danlos syndrome
Mariia Kumskova; Gagan D. Flora; Janice Staber; Steven R. Lentz; Anil K. Chauhan
Background
Easy bruising is included as a major or minor criterion for the classification of multiple types of Ehlers–Danlos syndrome (EDS). Despite a...
Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis
Asim Cengiz Akbulut; Ryanne A. Arisz; Constance C. F. M. J. Baaten; Gaukhar Baidildinova; Aarazo Barakzie; Rupert Bauersachs; Jur ten Berg; Wout W. A. van den Broek; H. C. de Boer; Amandine...
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
Abstract
Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the...
Preprint. Now published - see post #18
This is from Maureen Hanson's group.
Abstract
In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue, and reduces risk of chronic diseases. Although exercise is suggested as a lifestyle...
A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model
HIGHLIGTS
Imaging flow cytometry utilizing a novel rapid flow cytometric detection method is a promising method for detecting amyloid fibrin(ogen) microclots in conditions associated with...
Monitoring circulating platelet activity to predict cancer-associated thrombosis
Li; Lu; Yang; Zhang; Wang; Chu; Wang; Qi; Anderson; Jiang; Song; Nie; Li
A characteristic clinical complication in cancer patients is the frequent incidence of thrombotic events. Numerous studies have shown...
Exploring microplastic impact on whole blood clotting dynamics utilizing thromboelastography
Christodoulides, Alexei; Hall, Abigail; Alves, Nathan J.
This study investigates the influence of microplastics on blood clotting. It addresses the lack of comprehensive research on the effects of...
Plasma from patients with pulmonary embolism show aggregates that reduce after anticoagulation
Baker, Stephen R.; Halliday, Georgia; Ząbczyk, Michal; Alkarithi, Ghadir; Macrae, Fraser L.; Undas, Anetta; Hunt, Beverley J.; Ariëns, Robert A. S.
Background
Microclots, a term also used for amyloid...
Uncertainties about the Roles of Anticoagulation and Microclots in Post-acute Sequelae of SARS-CoV-2 Infection
Jean M. Connors; Robert A.S. Ariëns
Three years after the start of the pandemic, approaches to the prevention and treatment of acute Covid-19 have been established. However, post-acute...
Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?
Gerencer, Marijan; McGuffin, Liam J.
The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that...
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