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Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying...

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications Post-acute sequelae of COVID-19 (PASC) disproportionately affect hospitalized patients and require improved molecular characterization to inform patient management...

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection Abstract Background Glucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that...

Soluble Thrombomodulin Links Viremia and Mortality During COVID‐19: Results From the ACTIV‐4a Trial BACKGROUND COVID‐19 and other respiratory viral infections can cause cardiovascular complications. SARS‐CoV‐2 virions are found in the blood, and circulating viral RNA levels are associated with...

Immune-metabolic trajectories delineate subgroups in paediatric long COVID Most children and adolescents recover rapidly from SARS-CoV-2 infection, yet a subset develops paediatric long COVID (LC). How immune ontogeny shapes LC biology and heterogeneity remains unclear. We deeply phenotype a...

Abstract Persistent symptoms following SARS-CoV-2 infection are the hallmark of post-COVID condition (PCC), also referred to as long COVID. However, the underlying molecular mechanisms remain poorly understood. In this study, we employed data-independent acquisition mass spectrometry...

Personalized Exercise Training Modulates Red Blood Cell Rheology and Morphology in Long COVID Long COVID is associated with persistent fatigue, exercise intolerance, and microcirculatory dysfunction. Altered red blood cell (RBC) rheology, including impaired deformability and increased...

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients Abstract Chronic persistence of systemic symptoms after recovery from active CoVID-19 has become a significant disease burden, named post-CoVID syndrome...

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis MOTIVATION Long COVID is a multisystem condition characterized by persistent symptoms such as fatigue, cognitive impairment, and systemic inflammation following COVID-19 infection. However, its...

Platelet defects in patients and mice with Ehlers-Danlos syndrome Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders characterized by joint hypermobility, skin hyperelasticity, perivascular tissue fragility, easy bruising, and increased bleeding risk. Abnormal bleeding in...

Background and Objectives: Post-COVID-19 syndrome (PCS), characterized by persistent fatigue, can develop after a SARS-CoV-2 infection. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, post-infectious condition marked by severe fatigue and post-exertional malaise. This...

CD169+ and HLA-DR+ extracellular vesicles are highly represented in human plasma and dynamically expressed in SARS-CoV-2 infection and long COVID-associated sequelae INTRODUCTION Elevated inflammation and immune dysregulation are the main consequences of severe acute respiratory syndrome...

Widespread ncaas Imprints in the Serum Proteome of COVID-19 Convalescents Uncovering Immune System Sequelae Post-COVID-19 sequelae has become an emerging global health issue, but the mechanisms for the sustained susceptibility of convalescents to the sequelae remain poorly understood. Here we...

Now published - link here Preprint Inflammatory Triggers, Cell Death, Membrane Damage and Lipid Asymmetry That Shape Procoagulant Surfaces for Amyloidogenic Microclotting Etheresia Pretorius,Chantelle Venter,Jean M. Nunes,Alain R. Thierry,Douglas B. Kell Abstract Hypercoagulability...

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID Long COVID affects a substantial proportion of survivors of acute infection with severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2), who suffer a variety of symptoms that limit their...

Salivary cortisol in long COVID: a marker of broader stress system and circadian rhythm dysregulation INTRODUCTION Long COVID (LC) has been associated with hypothalamic–pituitary–adrenal (HPA) axis dysfunction, although findings from blood cortisol measurements remain inconsistent. We...

A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystem illnesses with overlapping symptoms and poorly understood...

Long COVID and Reduced Thrombosis in Antihistamine Treated Patients: An Observational Study in the Metropolitan Area of Barcelona BACKGROUND Early evidence from a nursing home in Yepes (Toledo, Spain) indicated that antihistamines combined with azithromycin prevented deaths and...

Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19 Post-Acute Sequelae of COVID-19 (PASC), or “long COVID,” describes persistent symptoms following recovery from SARS-CoV-2 infection. Early identification of circulating biomarkers...

Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID Long COVID, or post-acute sequelae of COVID-19 (PASC), is a major global health problem, with cumulative estimates suggesting that around 400 million people worldwide have been affected...