covid-19

SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases Iles J, Zmuidinaite R, Sadee C, Gardiner A, Lacey J, Harding S, Ule J...

Nebivolol: an effective option against long-lasting dyspnoea following COVID-19 pneumonia - a pivotal double-blind, cross-over controlled study Dal Negro RW, Turco P, Povero M Background: Pulmonary microvascular occlusions can aggravate SARS-CoV-2 pneumonia and result in a variable decrease in...

Open Access Published: 08 January 2023 Sequence similarity between SARS-CoV-2 nucleocapsid and multiple sclerosis-associated proteins provides insight into viral neuropathogenesis following infection Camille M. Lake & Joseph J. Breen Scientific Reports volume 13, Article number: 389 (2023)...

SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition Miyu Moriyama, Carolina Lucas, Valter Silva Monteiro, Yale SARS-CoV-2 Genomic Surveillance Initiative, Akiko Iwasaki SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to...

People who haven't had COVID will likely catch XBB.1.5 – and many will get reinfected, experts say Variant XBB.1.5 is very contagious, meaning everyone is at risk even if you've already been infected. As the U.S. enters year 3 of the pandemic, here's an update on the state of COVID. KAREN...

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D Madeline J. Lee, Michelle W. Leong, Arjun Rustagi, Aimee Beck, Leiping Zeng, Susan Holmes,4 Lei S. Qi, Catherine A. Blish Natural killer (NK) cells are cytotoxic effector cells that target and...

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 Maher, Allison K; Burnham, Katie L; Jones, Emma M; Tan, Michelle MH; Saputil, Rocel C; Baillon, Laury; Selck, Claudia; Giang, Nicolas; Argüello, Rafael; Pillay, Clio; Thorley, Emma...

Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination Pascal Irrgang, Juliane Gerling, Katharina Kocher, Dennis Lapuente, Philipp Steininger, Katharina Habenicht, Monika Wytopil, Stephanie Beileke, Simon Schäfer, Jahn Zhong, George...

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five...

Association between SARS-CoV-2 Infection and Select Symptoms and Conditions 31 to 150 Days After Testing among Children and Adults Yongkang Zhang, Alfonso Romieu-Hernandez, Tegan K Boehmer, Eduardo Azziz-Baumgartner, Thomas Carton, Adi V. Gundlapalli, Julia Fearrington, Kshema Nagavedu...

Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection Kwan, Alan C.; Ebinger, Joseph E.; Wei, Janet; Le, Catherine N.; Oft, Jillian R.; Zabner, Rachel; Teodorescu, Debbie; Botting, Patrick G.; Navarrette, Jesse; Ouyang, David...

Full title: Association of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness Open access: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799116 Question How do patient-reported physical, mental, and social well-being compare...

Highlights • Hair cortisone significantly increased by 23% in response to the COVID-19 pandemic • Stress at the start of the pandemic associated with greater increases in cortisol • Increased cortisone more likely in people with previous mental health difficulties Abstract Background Research...

Diminished Antiviral Innate Immune Gene Expression in the Placenta Following a Maternal SARS-CoV-2 Infection Coler B, Tsung-Yen WU, Carlson L, Burd N, Munson J, Dacanay M, Cervantes O, Esplin S, Kapur RP, Feltovich H, Adams Waldorf KM Background: Coronavirus disease 2019 (COVID-19) is caused by...

Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA Patients infected...

SARS-CoV-2-specicific [sic] humoral immunity in convalescent patients with mild COVID-19 is supported by CD4+ T-cell help and negatively correlated with Alphacoronavirus-specific antibody titer Marcus Odendahl, Iris Endler, Beate Haubold, Roman N. Rodionov, Stefan R. Bornstein, Torsten Tonn...

A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19 Michael Mörz The current report presents the case of a 76-year-old man with Parkinson’s disease (PD) who died three weeks after receiving his third COVID-19 vaccination. The...

Background The majority of those infected by ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require hospitalisation. Most had a short-lived mild or asymptomatic infection, while others had symptoms that persisted for...

SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4) Kan Li, Liu Yao, Jin Wang, Hao Song, Yan-hong Zhang, Xue Bai, Kai Zhang, Dong-ming Zhou, Ding Ai, Yi Zhu Letter to Nature: Signal Transduction and Targeted Therapy Link | PDF

COVID-19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acid Moiseiwitsch N, Zwennes N, Szlam F, Sniecinski R, Brown A Background: Thrombogenicity is a known complication of COVID-19, resulting from SARS-Cov-2 infection...