covid-19

Premortem Skin Biopsy Assessing Microthrombi, Interferon I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage Jeffrey Laurence, Gerard Nuovo, Sabrina E. Racine-Brzostek, Madhav Seshadri, Sonia Elhadad, A. Neil Crowson, J. Justin...

Neurovascular injury with complement activation and inflammation in COVID-19 Myoung-Hwa Lee, Daniel P. Perl, Joseph Steiner, Nicholas Pasternack, Wenxue Li, Dragan Maric, Farinaz Safavi, Iren Horkayne-Szakaly, Robert Jones, Michelle N. Stram, Joel T. Moncur, Marco Hefti, Rebecca D. Folkerth...

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain Preprint Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in...

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery Justin J. Frere, Randal A. Serafini, Kerri D. Pryce, Marianna Zazhytska, Kohei Oishi, Ilona Golynker, Maryline Panis, Jeffrey Zimering, Shu Horiuchi, Daisy A. Hoagland, Rasmus Møller...

Multi-Disciplinary Collaborative Consensus Guidance Statement on the Assessment and Treatment of Cardiovascular Complications in Patients with Post-Acute Sequelae of SARS-CoV- 2 Infection (PASC) American Academy of Physical Medicine & Rehabilitation PDF Jonathan Whiteson, MD, Department of...

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00126-6/fulltext

Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes Edward Richardson, David García-Bernal, Eleonora Calabretta, Rubén Jara, Marta Palomo, Rebecca M Baron, Gregory Yanik, Jawed Fareed, Israel Vlodavsky, Massimo Iacobelli, Maribel...

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy (Non peer-reviewed) Jae Kyu Ryu, Elif G Sozmen, Karuna Dixit, Mauricio Montano, Yusuke Matsui, Yixin Liu, Ekram Helmy, Thomas J Deerinck, Zhaoqi Yan, Renaud Schuck, Rosa Meza Acevedo, Collin M...

https://www.cell.com/med/fulltext/S2666-6340(22)00167-2 Highlights 1.Approximately half of COVID-19 patients shed fecal RNA in the week after infection 2. 4% patients with COVID-19 shed fecal viral RNA 10 months after diagnosis. 3. Presence of fecal SARS-CoV-2 RNA is associated with...

moved thread Ok, but most of these studies are based on confirmed PCR tests which if I understand correctly require virus particles, not necessarily antibodies. On Twitter someone pointed me to this Danish preprint which found that 16% of patients reported fatigue and 13% concentration...

Patients with coronavirus disease 2019 (COVID-19) frequently develop acute encephalopathy and encephalitis, but whether these complications are the result from viral-induced cytokine storm syndrome or anti-neural autoimmunity is still unclear. In this study, we aimed to evaluate the diagnostic...

Title : N-Acetylcysteine to Combat COVID-19: An Evidence Review Link : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649937/ Abstract The novel coronavirus disease (COVID-19) is caused by a virus (SARS-Cov-2) and is known for inducing multisystem organ dysfunction associated with significant...

Abstract Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from...

The Pfizer press release reports that protection is achieved 28 days after initiation of the first dose of vaccine. Whereas you can develop covid within a few days of exposure, so the virus wins that race...

Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers Miguel Galan, Lorena Vigon, Daniel Fuertes, Marıa Aranzazu Murciano-Anton, Guiomar Casado-Fernandez, Susana Domınguez-Mateos, Elena Mateos, Fernando...

Evaluation of science advice during the COVID-19 pandemic in Sweden Nele Brusselaers, David Steadson, Kelly Bjorklund, Sofia Breland, Jens Stilhoff Sörensen, Andrew Ewing, Sigurd Bergmann & Gunnar Steineck Abstract Sweden was well equipped to prevent the pandemic of COVID-19 from becoming...

Highlights • Patients hospitalized for COVID-19 display marked impairment in endothelial function, which is persistent following recovery from the acute infection. • Red blood cells (RBCs) from patients with COVID-19 impair vascular function through mechanisms involving increased arginase 1...

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism Romy Kronstein‐Wiedemann, Marlena Stadtmüller, Sofia Traikov, Mandy Georgi, Madeleine Teichert, Hesham Yosef, Jan Wallenborn, Andreas Karl, Karin Schütze, Michael Wagner, Ali El‐Armouche, Torsten Tonn...

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W. J. Schreurs, Dwin G. B. Grashof, Harmen J. G. van de Werken, Giovanna Jona Lasinio, Daniel...

The Millions of People Stuck in Pandemic Limbo https://www.theatlantic.com/health/archive/2022/02/covid-pandemic-immunocompromised-risk-vaccines/622094/ In his newsletter Ed Yong writes: "I wrote a long feature about immunocompromised people—what they’ve been through, their frustrations, and...