covid-19

Moved post International Journal of Molecular Sciences Implication of Covid-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects by Annamaria Russo et al Abstract Several diseases (such as diabetes, cancer, and neurodegenerative disorders)...

This is the paper linked to the experiment of inoculating young adults with COVID early in 2020. Abstract: To establish a novel SARS-CoV-2 human challenge model, 36 volunteers aged 18-29 years without evidence of previous infection or vaccination were inoculated with 10 TCID50 of a wild-type...

Abstract Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured...

Abstract Background: Long COVID is a condition characterized by long-term sequelae persisting after the typical convalescence period of COVID-19. Previous reports have suggested the role of an unsatisfactory immune response and impaired viral clearance in the pathogenesis of long COVID...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...

Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials. A Systematic Review and Meta-analysis Julia W. Haas, PhD1,2; Friederike L. Bender, MS3; Sarah Ballou, PhD1,2; John M. Kelley, PhD1,4; Marcel Wilhelm, PhD3; Franklin G. Miller, PhD5; Winfried Rief, PhD3; Ted J...

Abstract Background Previous research has shown that psychological factors, such as stress and social support, are associated with greater susceptibility to viral respiratory illnesses and more severe symptoms. During the COVID-19 pandemic there has been a well-documented deterioration in...

Key Points Question What is the association of a COVID-19 diagnosis and mobility and physical function among community-living middle-aged and older Canadians during the initial pandemic lockdown in 2020? Findings This cohort study of 24 114 participants found that community-living...

Abstract This document provides an update to the recommendations for physiotherapy management for adults with coronavirus disease 2019 (COVID-19) in the acute hospital setting. It includes: physiotherapy workforce planning and preparation; a screening tool for determining requirement for...

Desperate Patients Are Shelling Out Thousands for a Long Covid Cure. Is It for Real? Two doctors, their unusual treatment program, and the “wild bisons” who swear by it. by Kiera Butler January 3, 2022...

Preprint Abstract COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC)4-5. However, the burden of infection outside the respiratory tract and time to viral clearance is...

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 Lize M. Grobbelaar, Chantelle Venter, Mare Vlok, Malebogo Ngoepe, Gert Jacobus Laubscher, Petrus Johannes Lourens, Janami Steenkamp, Douglas B. Kell and Etheresia...

Platelets amplify endotheliopathy in COVID-19 Tessa J. Barrett, MacIntosh Cornwell, Khrystyna Myndzar, Christina C. Rolling, Yuhe Xia, Kamelia Drenkova1, Antoine Biebuyck, Alexander T. Fields, Michael Tawil, Elliot Luttrell-Williams, Eugene Yuriditsky, Grace Smith, Paolo Cotzia, Matthew D. Neal...

Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19 Nishikawa, M., Kanno, H., Zhou, Y. et al. Abstract A characteristic clinical feature of COVID-19 is the frequent incidence of microvascular thrombosis. In fact, COVID-19...

Abstract The more we learn about the new coronavirus infection, the more we understand that we will feel the echoes of the pandemic for many years, and those who have successfully endured the acute phase of COVID-19 may face the consequences of the infection. One of the most frequent...

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 Leo Swadling, et al. Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells...

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Overview of the Main Anti-SARS-CoV-2 Vaccines: Mechanism of Action, Efficacy and Safety Mascellino MT, Di Timoteo F, De Angelis M, Oliva A Infect Drug Resist. 2021;14:3459-3476. Published 2021 Aug 31 DOI 10.2147/IDR.S315727 Full Text

Another fantastic article by Ed Yong, on the abysmal experience of health care workers dealing with gaslighting and denial from their colleagues. Very similar to Royal Free and other outbreaks, just on a much larger scale. It seems that health care workers do not like being treated like they...

Abstract Several studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19...