covid-19

Abstract Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from...

The Pfizer press release reports that protection is achieved 28 days after initiation of the first dose of vaccine. Whereas you can develop covid within a few days of exposure, so the virus wins that race...

Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers Miguel Galan, Lorena Vigon, Daniel Fuertes, Marıa Aranzazu Murciano-Anton, Guiomar Casado-Fernandez, Susana Domınguez-Mateos, Elena Mateos, Fernando...

Evaluation of science advice during the COVID-19 pandemic in Sweden Nele Brusselaers, David Steadson, Kelly Bjorklund, Sofia Breland, Jens Stilhoff Sörensen, Andrew Ewing, Sigurd Bergmann & Gunnar Steineck Abstract Sweden was well equipped to prevent the pandemic of COVID-19 from becoming...

Highlights • Patients hospitalized for COVID-19 display marked impairment in endothelial function, which is persistent following recovery from the acute infection. • Red blood cells (RBCs) from patients with COVID-19 impair vascular function through mechanisms involving increased arginase 1...

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism Romy Kronstein‐Wiedemann, Marlena Stadtmüller, Sofia Traikov, Mandy Georgi, Madeleine Teichert, Hesham Yosef, Jan Wallenborn, Andreas Karl, Karin Schütze, Michael Wagner, Ali El‐Armouche, Torsten Tonn...

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W. J. Schreurs, Dwin G. B. Grashof, Harmen J. G. van de Werken, Giovanna Jona Lasinio, Daniel...

The Millions of People Stuck in Pandemic Limbo https://www.theatlantic.com/health/archive/2022/02/covid-pandemic-immunocompromised-risk-vaccines/622094/ In his newsletter Ed Yong writes: "I wrote a long feature about immunocompromised people—what they’ve been through, their frustrations, and...

Moved post International Journal of Molecular Sciences Implication of Covid-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects by Annamaria Russo et al Abstract Several diseases (such as diabetes, cancer, and neurodegenerative disorders)...

This is the paper linked to the experiment of inoculating young adults with COVID early in 2020. Abstract: To establish a novel SARS-CoV-2 human challenge model, 36 volunteers aged 18-29 years without evidence of previous infection or vaccination were inoculated with 10 TCID50 of a wild-type...

Abstract Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured...

Abstract Background: Long COVID is a condition characterized by long-term sequelae persisting after the typical convalescence period of COVID-19. Previous reports have suggested the role of an unsatisfactory immune response and impaired viral clearance in the pathogenesis of long COVID...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...

Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials. A Systematic Review and Meta-analysis Julia W. Haas, PhD1,2; Friederike L. Bender, MS3; Sarah Ballou, PhD1,2; John M. Kelley, PhD1,4; Marcel Wilhelm, PhD3; Franklin G. Miller, PhD5; Winfried Rief, PhD3; Ted J...

Abstract Background Previous research has shown that psychological factors, such as stress and social support, are associated with greater susceptibility to viral respiratory illnesses and more severe symptoms. During the COVID-19 pandemic there has been a well-documented deterioration in...

Key Points Question What is the association of a COVID-19 diagnosis and mobility and physical function among community-living middle-aged and older Canadians during the initial pandemic lockdown in 2020? Findings This cohort study of 24 114 participants found that community-living...

Abstract This document provides an update to the recommendations for physiotherapy management for adults with coronavirus disease 2019 (COVID-19) in the acute hospital setting. It includes: physiotherapy workforce planning and preparation; a screening tool for determining requirement for...

Desperate Patients Are Shelling Out Thousands for a Long Covid Cure. Is It for Real? Two doctors, their unusual treatment program, and the “wild bisons” who swear by it. by Kiera Butler January 3, 2022...

Preprint Abstract COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC)4-5. However, the burden of infection outside the respiratory tract and time to viral clearance is...

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 Lize M. Grobbelaar, Chantelle Venter, Mare Vlok, Malebogo Ngoepe, Gert Jacobus Laubscher, Petrus Johannes Lourens, Janami Steenkamp, Douglas B. Kell and Etheresia...