decodeme

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 6p Chr6p contained seven Tier 1 genes. ******************** HFE (Tier 1) • Protein: Homeostatic iron regulator protein. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with increasing HFE...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 20 Chr20 contained seven Tier 1 genes. *************** CSE1L (Tier 1) • Protein: Chromosome segregation 1-like (also known as exportin-2). UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated...

DecodeME candidate ME gene From the Candidate Genes document CHROMOSOME 17 Chr17 contained one Tier 1 gene. **************** CA10 (Tier 1) • Protein: Carbonic anhydrase-related protein 10. UniProt. GeneCards. Note that this gene encodes a protein that lacks catalytic activity. The allele...

DecodeMe Candidate Gene CHROMOSOME 15 Chr15 contained no Tier 1 genes and one Tier 2 gene. ********************* CCPG1 (Tier 2) • Protein: Cell cycle progression 1. UniProt. GeneCards. • Molecular function: Involved in positive regulation of cell cycle and positive regulation of cell...

DecodeMe Candidate Gene CHROMOSOME 13 Chr13 contained no Tier 1 genes and one Tier 2 gene. ******************** OLFM4 (Tier 2) • Protein: Olfactomedin-4. UniProt. GeneCards. • Molecular function: OLFM4 facilitates cell adhesion, most probably through interaction with cell surface lectins...

CHROMOSOME 12 (GWAS-2) Chr12 contained three Tier 1 genes. Image of the 2025 DecodeME results by @ME/CFS Science Blog: ******************** SUDS3 (Tier 1) • Protein: SIN3A corepressor complex component, also known as SDS3. UniProt. GeneCards. The allele that increases the risk of ME/CFS is...

DecodeME candidate ME/CFS gene ******************** FBXL4 (Tier 2) • Protein: F-box/LRR-repeat protein 4. UniProt. GeneCards. • Molecular function: Component of the mitochondria-localised SCF-FBXL4 ubiquitin E3 ligase complex. This complex restricts mitophagy by controlling the degradation...

DecodeME identified variants that passed the genome-wide significance threshold at this locus: DecodeME candidate ME/CFS gene CHROMOSOME 6p Chr6p contained seven Tier 1 genes. *************************** BTN2A2 (Tier 1) • Protein: Butyrophilin subfamily 2 member A2. UniProt. GeneCards...

From DecodeME Candidate Genes: RABGAP1L (Tier 1) • Protein: RAB GTPase-activating protein 1-like, also known as TBC1D18. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with decreasing RABGAP1L gene expression. • Molecular function: GTP-hydrolysis activating...

The DecodeME site FAQs page has a donation link that goes here to an Action for ME website page that says: 'Help change lives. Help us build on the work of DecodeME by supporting future research into ME/CFS. Donations will be managed by Action for ME, and used towards research projects delivered...

Initial posts have been moved from DecodeME in the Media **************************************************************************** Science Media Centre (featuring Sour-Grapes Carson, of course)...

[Additional line breaks added] ABSTRACT Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a common, poorly understood disease that has no effective treatments, and has long been underserved by scientific research and national health systems. It is a sex-biased disease towards...

Shortened version– read the full blog here. Scientists, people with ME/CFS, and their charities came together to create DecodeME, the world's biggest ME/CFS study – and its results are striking. 18,000 people with ME/CFS gave their DNA, enabling DecodeME to reveal eight genetic signals for the...

This thread is for media and social media items about DecodeME following the release of the results, and for discussion about the media items. For the analysis of the DecodeME results, there will be a research thread for the paper which we will link here. Edit: The preprint thread here...

From the moderation team This thread has been created to provide a way for members to be alerted when a DecodeME preprint is posted. To be alerted, 'watch' the thread (by clicking 'watch thread' at the top right of the thread). You can choose to receive an email as an alert. Posts will be made...

Jennie Jacques speaks with @Chris Ponting on DecodeME and the recent Biobank preprint Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity

We have existing threads for general discussion of DecodeME, UK: DecodeME updates, was recruitment thread., and the first publication from the study, Typing myalgic encephalomyelitis by infection at onset: A DecodeME study, 2023, Bretherick et al What I want to highlight with this thread is...

Given the possible importance of the DecodeME data I have opened this thread for users that might have ideas for possible projects with this data. I can’t claim to know what projects would even be possible or sensible, especially since I had never heard of PrecisionLife of iciHHV-6 before the...

This is a study making use of samples collected by DecodeME, where participants agreed that samples could be shared with other researchers. Summary - REQ001 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two, closely related viruses that infect humans. We often refer to them collectively...

I felt like writing about this. In my opinion ME/CFS is probably a label for several different poorly understood illnesses that happen to share some characteristics and which do not yet have their own name. We might call them subtypes of ME/CFS. Then, in a ME/CFS cohort there is probably also a...