fibromyalgia

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing...

Fibromyalgia and hand diseases: A case-control study Eli Magen, Suhail Aamar, Viktor Feldman, Israel Magen, Eugene Merzona, Ariel Israel [Line breaks added[ Highlights • FM triples risk of carpal tunnel, De Quervain’s, and trigger finger. • FM linked to higher rates of carpal tunnel release...

Abstract Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk...

Tonmya is the first FDA-approved therapy for the treatment of fibromyalgia in over 15 years https://www.globenewswire.com/news-release/2025/08/15/3134450/28908/en/Tonix-Pharmaceuticals-Announces-FDA-Approval-of-Tonmya-cyclobenzaprine-HCl-sublingual-tablets-for-the-Treatment-of-Fibromyalgia.html

Prospective associations between major depressive disorder, generalized anxiety disorder, fibromyalgia, and myalgic encephalomyelitis/chronic fatigue syndrome Nathaniel Stembridge Thomas, Michael C. Neale, Kenneth S. Kendler, Hanna M. van Loo, Nathan A. Gillespie Background Functional...

Circulating FGF-21 as a Disease-Modifying Factor Associated with Distinct Symptoms and Cognitive Profiles in Myalgic Encephalomyelitis and Fibromyalgia Myalgic encephalomyelitis (ME) and fibromyalgia (FM) are overlapping syndromes characterized by persistent fatigue, cognitive difficulties...

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism...

Thought we should have a thread for this trial as it is often cited as evidence of efficacy of LDN in fibromyalgia. Randomized Controlled Trial Arthritis Rheum. 2013 Feb;65(2):529-38. doi: 10.1002/art.37734. Low-dose naltrexone for the treatment of fibromyalgia: findings of a small...

*This post is in the process of being updated. People have given me feedback that sharing the Bluesky/Twitter threads is not a preferred/accessible option, so I will try to convey the relevant info here (it will likely have to be spread across multiple threads focusing on sub-topics). This will...

Multifaceted evolution focused on maximal exploitation of domain knowledge for the consensus inference of Gene Regulatory Networks Adrián Segura-Ortiz, Karen Giménez-Orenga, José García-Nieto, Elisa Oltra, José F. Aldana-Montes [Line breaks added] Highlights • BIO-INSIGHT optimizes GRN...

Recognizing the role of fibromyalgia in post-exertional malaise Alessandro Giollo; Mariangela Salvato; Andrea Doria The recent opinion by Charlton et al. published in Trends in Endocrinology & Metabolism [1] provides a thought-provoking discussion of the overlap between long coronavirus disease...

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan Abstract Objectives: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...

This is disapointing… …"This implies that experience of trauma and distress might elicit a specific immune-biological response in genetically or otherwise (eg, past infection, toxicity, trauma) vulnerable individuals, which includes the production of harmful noninflammatory autoantibodies." …...

ABSTRACT Background Functional medical disorders (FMDs) refer to persistent physical symptoms that cause impairment or disability, but which cannot be explained by routine medical testing. Negative perceptions towards FMDs exist amongst a variety of healthcare professionals, including medical...

https://www.sciencedirect.com/science/article/abs/pii/S1542012425000850 The Ocular Surface Volume 38, October 2025, Pages 64-71 Heightened visual light sensitivity discomfort measured by the ocular photosensitivity analyzer is associated with chronic ocular pain Ema V. Karakoleva a b c...

Abstract Fibromyalgia syndrome (FMS) is a chronic pain disorder characterised by widespread musculoskeletal pain, fatigue, and cognitive dysfunction, with no definitive biomarkers or mechanism-based treatments. Emerging evidence suggests that immune dysregulation may contribute to the FMS...

Interesting article on how ‘Central Sensitivity Syndromes’ evolved by Rheumatologists Milton Cohen and John Quintner from 2018. Seems this theory has fallen away somewhat in the last few years. ‘In 2007, Dr Mohammed Yunus from Illinois noted that a number of diverse, medically controversial...

The pivotal role of central sensitization in long COVID, fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome Don L. Goldenberg Introduction Long COVID is a condition characterized by persistent unexplained symptoms following COVID-19 infection. These symptoms are not related to...

Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive Berwick, Richard J.; Sahbaie, Peyman; Kenny, Grace; Guo, Tian-Zhi; Neiland, Harvey; Andersson, David A.; Clark...

Low-Dose Naltrexone for Severe Fibromyalgia Syndrome: A Report of a Case With Two-Year Follow-Up Ulrich Moser [Line breaks added] Abstract Fibromyalgia syndrome (FMS) is characterized by diffuse musculoskeletal pain associated with daytime fatigue, sleep disturbance, cognitive deficits, and...