gwas

Genome‐Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID‐19 ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although...

A genome-wide association study identifies novel genetic variants associated with neck or shoulder pain in the UK biobank (N = 430,193) Introduction: Neck and shoulder pain are prevalent musculoskeletal disorders that significantly affect the quality of life for a substantial portion of the...

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy Abstract Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we...

Integrative genetic analysis identifies shared regulation of DNA methylation and gene expression in migraine risk Ghaffar, Ammarah; Nyholt, Dale R. Abstract Background Migraine affects approximately 14% of adults, but the molecular mechanisms underlying susceptibility remain incompletely...

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological...

Citation: Dudbridge, Frank, et al. "Adjustment for index event bias in genome-wide association studies of subsequent events." Nature communications 10.1 (2019): 1561. Authors: Frank Dudbridge, Richard J. Allen, Nuala A. Sheehan, A. Floriaan Schmidt, James C. Lee,. Gisli Jenkins , Louise V. Wain...

Genetic evidence that advanced COVID-19 accelerates longitudinal brain atrophy: A Mendelian randomization study Abstract Coronavirus disease 2019 (COVID-19) was reported to persist long-term in the brain and leave several long-term neurologic sequelae. However, the causal relationship between...

Abstract Genome-wide association studies (GWAS) have yielded unprecedented insight into the genetic variants associated with many human traits. However, translating this insight into knowledge about causal biological mechanisms remains challenging. One promising recent strategy is to link...

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association...

https://www.actionforme.org.uk/register-for-the-prime-international-symposium/ Register for the PRIME International Symposium! 11 June 2026 Researchers, clinicians, industry representatives, charities and people with lived experience of ME/CFS will come together this September for the PRIME...

I had a closer look at the genetic data on ME/CFS in the Million Veterans Program (MVP). It includes data on more than half a million US veterans. Around 90% are male with a mean age of 62, so a very different cohort to DecodeME. The main results are reported in Verma et al. 2024...

Since the DecodeME preprint was released, I have been teaching myself bioinformatics by analyzing the summary statistics from DecodeME and other GWAS. I’ve been publishing my code on GitHub here, and documenting my results here. While I don’t have dramatic headline results, I still thought that...

Biological Insights from Genome-Wide Association Studies and Whole Genome Sequencing of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Maccallini, Paolo Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder of poorly understood etiology. We...

Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study Background Irritable bowel syndrome (IBS) significantly impacts individuals due to its prevalence and negative effect on quality of life. Current...

A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder Abstract Migraine is a neurovascular disorder that poses a high burden to Veterans, who face a greater risk than sex-matched...

A gene-based association method for mapping traits using reference transcriptome data Abstract Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in...

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions Abstract Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. We report results of a large meta-analysis...

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder and phobias) are highly prevalent, often onset early and...

HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data...

Mapping the genetic landscape across 14 psychiatric disorders Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar...