hla

Objective Functional somatic syndromes (FSS) are highly prevalent across all levels of healthcare. The fact that they are characterised by medically unexplained symptoms, such as fatigue and pain, raises the important question of their underlying pathophysiology. Psychosocial stress represents...

Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19? Gerencer, Marijan; McGuffin, Liam J. The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that...

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection Abstract Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic1,2,3,4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic...

Full title: At the Root of 3 “Long” Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome ABSTRACT: Several foreign antigens such as those derived from viruses and bacteria have been linked to...

I would like to share with you my latest review article. The Epstein-Barr virus (EBV) has long been known to be behind the development of autoimmune diseases, cancer and is even suspected to be behind the development of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Long COVID. But it is...

Full title: No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of...

Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci Abstract The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but...

PhD thesis https://www.duo.uio.no/bitstream/handle/10852/86195/1/PhD-Lande-2021.pdf https://www.duo.uio.no/bitstream/handle/10852/86195/PhD-Lande-2021.pdf Summary Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious and complex disease characterized by medically...

https://www.nature.com/articles/s41598-020-62157-x

New blog at ME/CFS Research Review Dr Ron Davis has won a large NIH (US National Institutes of Health) grant for an immunology project with a strong focus on HLA genes. Which may have led some to wonder, ‘What are they?’ HLA (human leukocyte antigen) molecules play a critical role in the...

I'm been reading Shoemaker and doing bits of his protocol lately, with some (limited) success. One aspect of his theory I've been curious about is his assertion that HLA types can play a role in treatment efficacy if not disease severity. Having believed Amy Yasko back in the day I'm more...