il-6

IL-6 family cytokines behind acute COVID-19 and Long COVID syndrome: Mechanisms, biomarkers, and intervention strategies Bustos, Matilde; Rodríguez-Hernández, María Ángeles Highlights IL-6 family cytokines differentially contribute to COVID-19 and Long COVID. Biomarker strength differs among...

Unpacking The Neurobiologic Origin Of Psychiatric Symptoms In Long Covid Claire Megan Perry Background Neuropsychiatric Long COVID (LC) is a heterogeneous and debilitating disease spanning multiple mental health symptom domains including depression, anxiety, cognitive dysfunction, fatigue, and...

Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis Epithelial mechanosensation maintains tissue homeostasis by sensing mechanical stimuli. Dysregulated mechanotransduction has been implicated in chronic pain, yet...

Investigation of MMP-3, IL-6, IL-6R, and TNF-Alpha Levels in Fibromyalgia Patients Presenting to a Physical Medicine and Rehabilitation Clinic Background Fibromyalgia syndrome (FMS) is a syndrome that commonly affects the musculoskeletal system and is characterized by fatigue and body aches...

Background Fatigue persists as a dominant and debilitating phenomenon in long-COVID, yet its underlying biological mechanisms remain unclear. While inflammatory variables tend to normalize within months post-infection, fatigue continues to significantly impact quality of life. Understanding...

IL-6 Receptor Antagonists and Severe Post-COVID-19 Outcomes: An Emulated Target Trial BACKGROUND Interleukin-6 (IL-6) is a cytokine that plays a key role in systemic hyperinflammation and may mediate the relationship between acute COVID-19 and severe long-term outcomes such as Long COVID or...

Abstract Post-acute sequelae of Covid-19 (PASC) refer to persistent symptoms lasting weeks to months after acute SARS-CoV-2 infection. However, identifying biological mechanisms, potential therapeutic targets, and modifiable environmental risk factors remains necessary. Here, we analyzed...

Choroid plexus alterations in long COVID and their associations with IL-6 [Line breaks added] Abstract SARS-CoV-2 disrupts the choroid plexus (ChP) epithelium by binding to the ACE-2 receptor, causing blood cerebrospinal fluid barrier leakage and permitting interleukin (IL)-6 and pathogens...

Peripheral Levels of Selected Biomarkers in Patients with Post-Sarcoidosis Chronic Fatigue Syndrome [Line breaks added] Introduction Chronic fatigue syndrome (CFS) is characterized by persistent fatigue and multiple symptoms such as cognitive impairment and muscle pain, often linked to...

Association of TLR9-rs352140 Polymorphism and Serum Levels of CRP, IL-6, and Anti-RBD IgG with the Chance of Developing Long COVID-19 Syndrome Zeynab Alavitabar, Hamed Fouladseresht, Amaneh Javid, Ensiye Torki, Majid Hosseinzadeh Background Long COVID-19 syndrome (LCS) is characterized by a...

Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19 Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, Ji Yeun Kim, Woori Kim, Ju Yeon Son, Junho Cha, Choi Young Jang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim...

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis Eltobgy, Mostafa M.; Zani, Ashley; Kenney, Adam D.; Estfanous, Shady; Kim, Eunsoo; Badr, Asmaa; Carafice, Cierra; Daily, Kylene; Whitham, Owen; Pietrzak, Maciej; Webb, Amy; Kawahara...

Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine Jolink; Feldman; Antenucci; Cardenas; West; Nakamura; Muscatell The influenza vaccine has reliably been associated with mild, within-person increases in...

Meningeal lymphatics-microglia axis regulates synaptic physiology Kyungdeok Kim; Daviti Abramishvili; Siling Du; Zachary Papadopoulos; Jay Cao; Jasmin Herz; Igor Smirnov; Jean-Leon Thomas; Marco Colonna; Jonathan Kipnis SUMMARY Meningeal lymphatics serve as an outlet for cerebrospinal fluid...

The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review Thiago Henrique Teodoro, Katerine Palharini Manfrin Costa, Jonato Prestes, Jos Campanholi, James Navalta, Guilherme Borges Pereira Purpose: Imbalance between Th1 and Th2 cells...

340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park Background As the number of COVID-19 survivors amongst the global population continues to rise, the...

Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults Nicholas Donnelly, Ruby Tsang, Èimear M Foley, Holly Fraser, Aimee Hanson, Golam M Khandaker Background Depression is associated with alterations in immuno-metabolic biomarkers, but it remains...

Involvement of oxidative stress in post-acute sequelae of COVID-19: clinical implications Paola Mayara Valente Coronel, Denise Caroline Luiz Soares Basilio, Isabelly Teixeira Espinoça, Kamylla Fernanda Souza de Souza, Nathalia Miranda Campos, Rafael Seiji Nakano Ota, Edgar Julian...

Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection Lokau, Juliane; Garbers, Yvonne; Vicente, Manuel M.; Dittrich, Anna; Meltendorf, Stefan; Lingel, Holger; Münster-Kühnel, Anja K.; Brunner-Weinzierl, Monika; Garbers, Christoph INTRODUCTION...

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer...