inflammation

From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity Müller, Ludmila; Di Benedetto, Svetlana The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. This mini-review...

Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia Francesca Sciarretta; Fabio Zaccaria; Andrea Ninni; Veronica Ceci; Riccardo Turchi; Savina Apolloni; Valerio Chiurchiu; Marta Tiberi; Nadia D'Ambrosi; Silvia...

SARS-CoV-2 induces acute neurological signs while Calcitonin Gene-Related Peptide CGRP signaling blockade reduces interleukin 6 IL-6 release and weight loss in mouse models Shafaqat M Rahman; David W Buchholz; Brian Imbiakha; Mason C Jaeger; Justin Leach; Raven M Osborn; Ann O Birmingham...

Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact...

N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues...

Vaccination after developing long COVID: impact on clinical presentation, viral persistence and immune responses Maryam Nayyerabadi; Lyvia Fourcade; Swarali A. Joshi; Prabha Chandrasekaran; Arpita Chakravarti; Chantal Massé; Marie-Lorna Paul; Joanie Houle; Amina M. Boubekeur; Charlotte DuSablon...

SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile Zhang, Jia-Yuan; Whalley, Justin P.; Knight, Julian C.; Wicker, Linda S.; Todd, John A.; Ferreira, Ricardo C. The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in...

pH sensing at the intersection of tissue homeostasis and inflammation Stephanie Hajjar; Xu Zhou pH is tightly maintained at cellular, tissue, and systemic levels, and altered pH – particularly in the acidic range – is associated with infection, injury, solid tumors, and physiological and...

Role of miR-2392 in driving SARS-CoV-2 infection J. Tyson McDonald; Francisco J. Enguita; Deanne Taylor; Robert J. Griffin; Waldemar Priebe; Mark R. Emmett; Mohammad M. Sajadi; Anthony D. Harris; Jean Clement; Joseph M. Dybas; Nukhet Aykin-Burns; Joseph W. Guarnieri; Larry N. Singh; Peter...

Attenuation of ferroptosis as a potential therapeutic target for neuropsychiatric manifestations of post-COVID syndrome Sousa, Ricardo A. L.; Yehia, Asmaa; Abulseoud, Osama A. Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), is...

Coronary “Microvascular Dysfunction”: Evolving Understanding of Pathophysiology, Clinical Implications, and Potential Therapeutics Kei, Chun Yeung; Singh, Kuljit; Dautov, Rustem F.; Nguyen, Thanh H.; Chirkov, Yuliy Y.; Horowitz, John D. Until recently, it has been generally held that stable...

Metabolic regulation of gene expression by histone lactylation Zhang, Di; Tang, Zhanyun; Huang, He; Zhou, Guolin; Cui, Chang; Weng, Yejing; Liu, Wenchao; Kim, Sunjoo; Lee, Sangkyu; Perez-Neut, Mathew; Ding, Jun; Czyz, Daniel; Hu, Rong; Ye, Zhen; He, Maomao; Zheng, Y. George; Shuman, Howard A...

Lactic acid in macrophage polarization: The significant role in inflammation and cancer Hai-cun Zhou; Xin-yan Yan ; Wen-wen Yu; Xiao-qin Liang; Xiao-yan Du; Zhi-chang Liu; Jian-ping Long; Guang-hui Zhao; Hong-bin Liu Metabolite lactic acid has always been regarded as a metabolic by-product...

Cortical thickness alterations and systemic inflammation define long-COVID patients with cognitive impairment Abstract As the heterogeneity of symptoms is increasingly recognized among long-COVID patients, it appears highly relevant to study potential pathophysiological differences along the...

No evidence for the association between COVID-19 and neuroinflammation: A diffusion basis spectrum imaging study. Wei Zhang; Aaron J Gorelik; Qing Wang; Sara A Norton; Tamara Hershey; Janine D Bijsterbosch; Ryan Bogdan COVID continues to be a major international public health concern, the...

Vagus nerve inflammation contributes to dysautonomia in COVID-19 Woo, Marcel S.; Shafiq, Mohsin; Fitzek, Antonia; Dottermusch, Matthias; Altmeppen, Hermann; Mohammadi, Behnam; Mayer, Christina; Bal, Lukas C.; Raich, Lukas; Matschke, Jakob; Krasemann, Susanne; Pfefferle, Susanne; Brehm, Thomas...

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling Perico, Luca; Morigi, Marina; Pezzotta, Anna; Locatelli, Monica; Imberti, Barbara; Corna, Daniela; Cerullo, Domenico; Benigni, Ariela; Remuzzi, Giuseppe The...

Full title: Chronic inflammation, neuroglia dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome Highlights Plasmalogens (Pls) are lipids containing a...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...

Abstract Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive...